Fig. 6

TAMP length associated to GO terms and protein conservation in H. sapiens. a Frequency distribution of TAMPs and non-TAMPs according to the lengths indicated below. Median length of TAMPs is 288 aa, while non-TAMPs have 432 aa (t-test, p < 4e^− 11). There is a bias exemplified by the shape of the distributions to a shorter length for TAMPs compared to non-TAMPs. b Enrichment of GO terms according to TAMP length. Proteins were binned according to their length such that each bin contains 143 proteins and a GO Term enrichment analysis relative to the same term for the human genome was performed for each length bin. Numbers in parentheses represent the total number of TAMPs annotated with that GO Term. c Profile of conservation across different human TAMP lengths. Each cell shows the percentage of the orthologs (a proxy of conservation) of the specified length (columns) from a given species (rows) that are predicted to be TAMPs. The enrichment of orthologs among TAMPs longer than 160 amino acids in both mammalians and non-mammalians suggests that the longer TAMPs are more conserved across species