Table 2 Validation in silico of TAMPfinder - TP, FP, FN, and TN represent true-positive, false-positive, false-negative, and true-negative values, respectively. Sensitivity = TP/(TP + FN); Specificity TN/(TN + FP)
Positive dataset (experimentally validated TAMPs) | ||||
|---|---|---|---|---|
| Â | H. sapiens | S. cerevisiae | A. thaliana | Total |
FN | 3 | 7 | 11 | 21 |
TP | 31 | 31 | 29 | 91 |
Sensitivity | 0.912 | 0.816 | 0.725 | 0.813 |
Negative Dataset 1 (secreted proteins) | ||||
| Â | H. sapiens | S. cerevisiae | A. thaliana | Total |
TN | 27 | 6 | 46 | 79 |
FP | 11,846 | 392 | 1761 | 13,999 |
Specificity | 0.998 | 0.985 | 0.975 | 0.994 |
Negative Dataset 2 (nuclear proteins) | ||||
| Â | H. sapiens | S. cerevisiae | A. thaliana | Total |
TN | 12 | 2 | 8 | 22 |
FP | 1512 | 823 | 661 | 2996 |
Specificity | 0.992 | 0.998 | 0.988 | 0.993 |
Negative Dataset 3 (cytoplasm proteins) | ||||
| Â | H. sapiens | S. cerevisiae | A. thaliana | Total |
TN | 4 | 1 | 0 | 5 |
FP | 486 | 305 | 203 | 994 |
Specificity | 0.992 | 0.997 | 1.0 | 0.995 |