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Fig. 3 | BMC Genomics

Fig. 3

From: MicroRNA-124-3p suppresses mouse lip mesenchymal cell proliferation through the regulation of genes associated with cleft lip in the mouse

Fig. 3

Effect of overexpression of the predicted miRNAs on cell proliferation. a Side (left) and frontal (right) view of mouse embryos at E10.5 and E11.5. The drawings on the right show a mouse head at each developmental stage. Color code: frontonasal process, green; maxillary process, red; nasal process, light blue; and mandibular process, gray. b, c Cell proliferation assays using MELM cells from E10.5 (B) and E11.5 (c) lips treated with the indicated miRNAs. Negative control (control, light blue), miR-124-3p (orange), let-7a-5p (gray), let-7b-5p (yellow), let-7c-5p (blue), and let-7d-5p (light green). ** p < 0.01, *** p < 0.001. s Immunoblotting analysis for cleaved caspase 3 in MELM cells treated with negative control (NC), miR-124-3p mimic, and positive control (PC). GAPDH was used as an internal control

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