Table 2 Enriched DE transcripts between P0 and P5
Tissue, system or organ | GO term | Gene name | Encoded protein – expression and function |
|---|---|---|---|
Immune system | Antigen processing and presentation | CD8A | Mediation of efficient cell-cell interactions within the immune system |
Mucosal immune response | PIGR | Facilitation of the transcytosis of soluble polymeric isoforms of immunoglobulin A and immune complexes | |
Thymic T cell selection; T cell selection | CD74 | Association with MHC class II and regulation of antigen presentation for the immune response | |
Blood tissue | Erythrocyte differentiation | AHSP | Molecular chaperone that binds specifically to free alpha-globin and is involved in haemoglobin assembly |
DYRK3 | Acts as a negative regulator of EPO-dependent erythropoiesis | ||
KLF1 | Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis | ||
Hearing | Cochlea development | HES1 | Expressed in the organ of Corti during its terminal differentiation |
PTK7 | Guides stereocilia orientation | ||
SOBP | Regulates the cellular fate and standardization of the organ of Corti | ||
Vision | Visual perception | AIPL1 | Expressed during rod and cone development |
CRYBA1, CRYBA4, CRYBB1, CRYBB2 | Crystallins are required for the development and maintenance of the transparency of the eye lens | ||
GJC1 | Expressed in retina bipolar cells and retinal ganglion cells during development | ||
Digestion | Gastric acid secretion | SLC9A4 | Required for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and, at least secondarily, for chief cell differentiation |
GAST | Gastrin is a hormone that stimulates the secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. Also acts as a mitogenic factor for gastrointestinal epithelial cells | ||
Excretory system | Metanephric nephron development | IRX1 | Expressed and required during different stages of pronephros development. Additionally, it is crucial in the regionalization and patterning of tissues and organs during metazoan development |
Nervous system | Midbrain development; regulation of astrocyte differentiation; regulation of glial cell differentiation | GPR37L1 | Expressed in neurons and glia |
Midbrain development | MSX1 | Related to the development of the midline structure of the forebrain, expressed in the spinal cord | |
Limbs | Embryonic hindlimb morphogenesis | FGF4 | Expressed in the thoracic and pelvic limbs and the apical ectodermal ridge of the limb bud |
MSX1 | Encodes transcription factors that are crucial for limb development |