Table 3 Enriched DE transcripts between P5 and P10
Tissue, system or organ | GO term | Gene name | Encoded protein – expression and function |
|---|---|---|---|
Immune system | Complement activation | C1S | Serine protease that is a major constituent of human complement subcomponent C1 |
C4BPA, C4BPB | Controls the classical pathway of complement activation | ||
C6 | Component of the complement cascade | ||
Mucosal immune response | PLA2G1B | Secreted member of the phospholipase A2 (PLA2) class of enzymes produced by the pancreatic acinar cells | |
RAB17 | The small Rab GTPases are key regulators of intracellular membrane trafficking from the formation of transport vesicles to their fusion with membranes | ||
Blood tissue | Blood coagulation | APOH | Binds to cardiolipin |
FGB, FGG | Plays a role in blood clotting and platelet aggregation | ||
HRG | Binds to numerous ligands and modulates immunity, vascularization and coagulation processes | ||
PDGFA | Regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis | ||
PROC, PROZ | Regulation of blood coagulation | ||
Fibrin clot formation | APOH | Binds to cardiolipin | |
FGB, FGG | Important for blood clotting and platelet aggregation | ||
Complement and coagulation cascade | F7 | Initiates the extrinsic pathway of blood coagulation | |
F9 | Participates in the intrinsic pathway of blood coagulation | ||
PLG | Plasminogen is activated by proteolysis and converted to plasmin and angiostatin | ||
Erythrocyte differentiation | AHSP | Prevents the harmful aggregation of alpha-haemoglobin during normal erythroid cell development | |
KLF1 | Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis | ||
Digestion | Fat digestion and absorption; glycerolipid metabolism | MOGAT3 | Catalyses the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA |
Excretory system | Regulation of kidney development | FAT4 | Plays a role in the orientation of cell divisions and tubule elongation during kidney development |