Table 2 Summary of GO terms enriched and the number of genes affected by the deletion of the CaPPZ1 gene under normal (KO vs WT) or oxidative stress conditions (KOt vs WTt), as well as by oxidative stress treatment of wild type (WTt vs WT) or of phosphatase deletion mutant (KOt vs KO) C. albicans strains
GO ID | GO TERM | 1st line: Number of up/down regulated genes | |||
|---|---|---|---|---|---|
2nd line: Cluster frequency (%) | |||||
3rd line: Corrected p value | |||||
KO vs WT | KOt vs WTt | KOt vs KO | WTt vs WT | ||
Membrane Transport | |||||
55085 | Transmembrane transporta | 12/0 | 34/0 | 22/3 | 4/1 |
23.5 | 12.8 | ||||
0.00614 | 0.01683 | ||||
5215 | Transporter activitya | 11/0 | 35/0 | 23/3 | 3/1 |
21.6 | 13.2 | ||||
0.01162 | 0.00212 | ||||
16021 | Integral component of membrane | 14/0 | 7/0 | 2/4 | 1/1 |
7.7 | |||||
0.00091 | |||||
Cell Surface | |||||
9986 | Cell surfacea | 0/0 | 0/45 | 0/58 | 0/10 |
19.1 | 14.5 | 15.4 | |||
4.2E-21 | 2.38e-21 | 0.00297 | |||
5618 | Cell walla | 0/0 | 0/38 | 0/50 | 0/9 |
16.1 | 12.5 | 13.8 | |||
2.85e-18 | 1.45e-19 | 0.00320 | |||
31012 | Extracellular matrix | 0/0 | 0/17 | 0/20 | 0/1 |
7.2 | 5.0 | ||||
1.95e-07 | 4.74e-06 | ||||
97311 | Biofilm matrix | 0/0 | 0/17 | 0/20 | 0/1 |
7.2 | 5.0 | ||||
1.95e-07 | 4.74e-06 | ||||
44403 | Symbiont processa | 0/0 | 0/15 | 0/22 | 0/2 |
5.5 | |||||
0.01879 | |||||
51701 | Interaction with host | 0/0 | 0/11 | 0/16 | 0/0 |
4.7 | 4.0 | ||||
0.01453 | 0.00167 | ||||
Metabolism | |||||
6520 | Cellular amino acid metabolic process | 0/1 | 1/0 | 0/4 | 0/11 |
16.9 | |||||
0.00141 | |||||
1901607 | Alpha-amino acid biosynthetic process | 0/0 | 13/0 | 21/0 | 3/0 |
3.9 | |||||
0.03642 | |||||
55086 | Nucleobase-containing small molecule metabolic process | 0/1 | 0/15 | 0/24 | 0/6 |
6.0 | |||||
0.02650 | |||||
97384 | Ergosterol biosynthetic process | 0/0 | 3/0 | 2/0 | 0/7 |
10.8 | |||||
1.55e-06 | |||||
6732 | Coenzyme metabolic process | 0/0 | 0/16 | 0/15 | 0/0 |
6.8 | |||||
0.04756 | |||||
6733 | Oxidoreduction coenzyme metabolic process | 0/0 | 0/14 | 0/15 | 0/0 |
5.9 | 3.7 | ||||
0.00026 | 0.04689 | ||||
16491 | Oxidoreductase activitya | 4/1 | 43/0 | 32/8 | 0/19 |
16.2 | 29.2 | ||||
8.93e-06 | 2.42e-06 | ||||
55114 | Oxidation-reduction process a | 6/0 | 51/0 | 62/0 | 12/2 |
19.2 | 11.6 | ||||
2.04e-10 | 0.00131 | ||||
Translation | |||||
3735 | Structural constituent of ribosome | 0/0 | 0/71 | 0/76 | 0/2 |
30.1 | 19.0 | ||||
8.96e-60 | 5.71e-48 | ||||
22685 | Cytosolic ribosome | 0/0 | 0/63 | 0/70 | 0/2 |
26.7 | 17.5 | ||||
1.33e-65 | 1.51e-60 | ||||
15934 | Large ribosomal subunita | 0/0 | 0/42 | 0/46 | 0/2 |
17.8 | 11.5 | ||||
7.71e-48 | 2.40e-25 | ||||
15935 | Small ribosomal subunita | 0/0 | 0/22 | 0/24 | 0/0 |
9.3 | 6.0 | ||||
8.13e-15 | 7.83e-12 | ||||
30684 | Preribosome | 0/0 | 18/25 | 85/0 | 24/0 |
15.9 | 18.2 | ||||
3.46e-45 | 4.31e-12 | ||||
16070 | RNA metabolic processa | 0/0 | 27/0 | 132/0 | 34/0 |
24.8 | 25.8 | ||||
3.36e-13 | 0.00792 | ||||
140098 | Catalytic activity, acting on RNA | 0/0 | 7/0 | 41/0 | 8/0 |
7.7 | |||||
0.00037 | |||||