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Table 3 Previously reported role of the candidate genes located in the genomic regions associated with RFI in Angus

From: Combining information from genome-wide association and multi-tissue gene expression studies to elucidate factors underlying genetic variation for residual feed intake in Australian Angus cattle

Genomic region (1 Mb)Candidate genesFunction
BTA20
3.88–5.88
DUSP1-Dual Specificity Phosphatase 1Up-regulated gene in muscle from efficient broilers [15] and adipose tissue from obese humans [16]
ERGIC1 - Endoplasmic Reticulum-Golgi Intermediate Compartment 1Associated with MMWT in cattle [10]
RPL26L1-Ribosomal Protein L26 Like 1Gene associated with MMWT in cattle [10] and up regulate in breast carcinoma [17]
STK10-Serine threonine kinase 10Significantly associated with slaughter weight in beef cattle [18]
ATP6V0E1- ATPase H+ Transporting V0 Subunit E1Involved in oxidative phosphorylation with up-regulation in rumen epithelium of low RFI cattle [19]
STC2-Stanniocalcin 2Associated with RFI and MBW in cattle [20]; possible modulator of carcass and meat quality traits in beef cattle [21]. Overexpression resulted in postnatal growth restriction in mice [22]
CPEB4- Cytoplasmic Polyadenylation Element Binding Protein 4Gene associated with rib eye area in Nelore [23]. Nearby a suggestive SNP (p-value 1.38e− 05) for average daily gain in pig [24]
NEURL1B- Neuralized E3 Ubiquitin Protein Ligase 1BAssociated with day 2 of preadipocyte differentiation in chicken [25], nearby gene to the single nucleotide variants associated with body mass index in adult humans [26], nearby gene to significant SNP for longissimus dorsi muscle area in Hanwoo cattle [27]
BOD1- Biorientation Of Chromosomes in Cell Division 1Inhibits PP2A-B56 regulating the function of Plk1 in mitotic cells at spindle poles and kinetochores [28]
BTA17
6.26–6.46
SDS- Serine Dehydratase, SDSL- Serine Dehydratase LikeLow expression in bovine jejunal epithelium tissue due to restricted dietary [29]
DTX1- Deltex E3 Ubiquitin Ligase 1Regulates transcription in the nucleus downstream the Notch receptor [30]
SLC8B1- Solute Carrier Family 8 Member B1Up-regulation in high-efficient broiler chickens [31]
OAS2–2′-5′-Oligoadenylate Synthetase 2Up-regulated in Blonde d’Aquitaine during embryonic muscle developmental when contrasting with Charolais [32]
PTPN11- Protein Tyrosine Phosphatase, Non-Receptor Type 11Down regulated gene in high-RFI Holstein [33], and control cell proliferation in postnatal mice [34]
RPL6- Ribosomal Protein L6Differentially expressed gene in divergent RFI lines of pigs [35]
LHX5- LIM Homeobox 5Regulates the development and distribution of Cajal-Retzius cells in the developing forebrain [36]
TPCN1- Two Pore Segment Channel 1Mice with knock down of the Tpcn1/2 had increase body mass due to faster increase in fat mass compare with the wile mice [37]
BTA14
2.31–2.51
XKR4- XK Related 4SNP associated with ADFI and ADG in cattle [38], and backfat thickness in Nelore [39]
SOX17- SRY-Box 17Transcriptional regulator of differentiation in embryonic stem cells in mouse [40]. Significant SNP associated with EBV for paternal calving ease in cattle [41]
BTA1
1.10–1.11
VEPH1- Ventricular Zone Expressed PH Domain Containing 1Candidate gene for rump fat thickness in Nellore [9]
PTX3- Pentraxin 3Up-regulated in breast muscle of high-feed efficient broilers [42]
MFSD1-Major facilitator superfamily domain containing 1Down-regulated gene in brainstem and hypothalamus of mice raised on high-fat diet [43]
BTA6
5.41–5.61
LOC104968862
LOC104968863
-un characterize proteins
Located in the region of SNPs for rump fat thickness [39]
BTA26
7.90–9.90
MINPP1- Multiple Inositol-Polyphosphate Phosphatase 1Maintains the levels of InsP5 and InsP6 which are essential to normal cell growth [44]
A1CF- APOBEC1 Complementation FactorSplicing regulator and the A1CF loss of function elevated triglycerides levels in mice [45]
PAPSS2–3′-Phosphoadenosine 5′-Phosphosulfate Synthase 2Gene located nearby a SNP associated with DMI in feedlot steers [46]; After treating cartilage from bovine with TGF-β, the expression of gene PAPSS2 was up-regulated in articular chondrocytes, while the expression was down-regulated in cartilage from mice with negative mutation of the TGF-β receptor [47]
SGMS1- Sphingomyelin Synthase 1Gene nearby a significant SNP associated with RFI in pigs [48] and average daily feed intake [49]
ASAH2- N-Acylsphingosine Amidohydrolase 2Up-regulated in pigs with low feed conversion ratio [50]
  1. 1Mb: 1 M base, BTA: Bos Taurus Autosome