Fig. 2

Translational and transcriptional responses to mTOR inhibition. a GO analysis of genes with significantly down-regulated translation upon inhibition of mTOR where the response is translational only (left), indicative of a primary response, or both translational and transcriptional (right), indicative of a secondary longer-term response (transcriptional-only comprised only 7 genes and were not analysed further) (b) Bar chart (left) shows the proportion of genes with significant down-regulation of translation that are trans-spliced (SL) for each response category in (a): TO = translation only; B = both translational and transcriptional response. Mosaic plot (right) visualises the Pearson residuals from a corresponding χ² test