Skip to main content

Table 2 Consensus when removing models trained on the associated test dataset

From: Improving CRISPR guide design with consensus approaches

  Wang   Doench
Consensus level n Accepted Precision Recall NPV Accepted Precision Recall NPV
1 1050 0.663 0.952 0.706 1751 0.205 0.968 0.867
2 857 0.712 0.835 0.612 1472 0.218 0.865 0.865
3 578 0.811 0.642 0.557 947 0.244 0.623 0.843
4 357 0.868 0.424 0.482 490 0.282 0.372 0.828
5 180 0.911 0.224 0.427 136 0.331 0.121 0.809
6 81 0.926 0.103 0.397 29 0.276 0.022 0.800
7 30 0.967 0.040 0.384 3 0.333 0.003 0.799
8 9 0.889 0.011 0.377 - - - -
9 1 1.000 0.001 0.375 - - - -
  1. Tools considered for Wang: Cas-Designer, WU-CRISPR, FlashFry, sgRNAScorer2, CHOPCHOP, CHOPCHOP-MM, TUSCAN, PhytoCRISP-Ex and mm10db. Tools considered for Doench: Cas-Designer, sgRNAScorer2, CHOPCHOP, CHOPCHOP-Xu, CHOPCHOP-MM, PhytoCRISP-Ex and mm10db