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Table 5 Consensus between machine-learning methods, removing models trained on the associated test dataset

From: Improving CRISPR guide design with consensus approaches

 

Wang

Doench

Consensus level n

Accepted

Precision

Recall

NPV

Accepted

Precision

Recall

NPV

1

927

0.695

0.881

0.641

1655

0.216

0.965

0.930

2

624

0.793

0.677

0.567

1242

0.241

0.806

0.880

3

295

0.881

0.356

0.461

653

0.254

0.447

0.827

4

120

0.892

0.146

0.405

221

0.290

0.173

0.811

5

20

0.950

0.026

0.380

-

-

-

-

  1. Tools considered for Wang: sgRNAScorer2, CHOPCHOP-MM, WU-CRISPR, FlashFry and TUSCAN. Tools considered for Doench: sgRNAScorer2, SSC, CHOPCHOP-MM and CHOPCHOP-Xu