A generative model for constructing nucleic acid sequences binding to a protein

BMC Genomics

Table 2 The median binding affinity AF of the generated sequences and random sequences to target protein p with AUC of DeepBind model of p

Protein	DRGX	GCM1	OLIG1	RXRB	SOX2	BHLHE23	MTF1	FOXP3
AUC	0.897	0.841	0.733	0.720	0.605	0.557	0.538	0.499
Median AF (Generated)	0.999	0.995	0.763	0.644	0.473	0.513	0.557	0.502
Median AF (Random)	0.497	0.500	0.504	0.494	0.504	0.501	0.502	0.501

ISSN: 1471-2164