TY - JOUR AU - Bashkeel, Nasser AU - Perkins, Theodore J. AU - Kærn, Mads AU - Lee, Jonathan M. PY - 2019 DA - 2019/12/07 TI - Human gene expression variability and its dependence on methylation and aging JO - BMC Genomics SP - 941 VL - 20 IS - 1 AB - Phenotypic variability of human populations is partly the result of gene polymorphism and differential gene expression. As such, understanding the molecular basis for diversity requires identifying genes with both high and low population expression variance and identifying the mechanisms underlying their expression control. Key issues remain unanswered with respect to expression variability in human populations. The role of gene methylation as well as the contribution that age, sex and tissue-specific factors have on expression variability are not well understood. SN - 1471-2164 UR - https://doi.org/10.1186/s12864-019-6308-7 DO - 10.1186/s12864-019-6308-7 ID - Bashkeel2019 ER -