Identification of highly conserved, serotype-specific dengue virus sequences: implications for vaccine design

BMC Genomics

Table 1 Number and distribution of redundant (R) and non-redundant (NR) reported DENV protein sequences in 2007 and 2018

Protein / Serotype	DENV1		DENV2		DENV3		DENV4		Total
Protein / Serotype	2018^R	2018^NR	2018^R	2018^NR	2018^R	2018^NR	2018^R	2018^NR	2007^R	2018^R	2018^NR	Increase (#\|%)^a	Reduction (#\|%)^b
C	3566	322	2061	312	1736	293	454	114	1278	7817	1041	6539 \| 511%	6776 \| 86.68%
prM	2651	364	2376	329	1787	168	659	89	1530	7473	950	5943 \| 388%	6523 \| 87.29%
E	2329	1074	5269	1533	2950	933	1724	543	3845	12,272	4083	8427 \| 219%	8189 \| 66.73%
NS1	2470	491	2190	488	1314	306	397	114	1784	6371	1399	4587 \| 257%	4972 \| 78.04%
NS2a	1982	411	1535	349	1012	207	334	97	705	4863	1064	4158 \| 589%	3799 \| 78.12%
NS2b	1978	155	1537	126	1019	87	259	38	614	4793	406	4179 \| 680%	4387 \| 91.53%
NS3	1976	404	1578	384	1204	309	276	92	695	5034	1189	4339 \| 624%	3845 \| 76.38%
NS4a	1949	141	1519	114	993	84	241	40	523	4702	379	4179 \| 799%	4323 \| 91.94%
NS4b	1952	193	1524	261	999	97	319	77	602	4794	628	4192 \| 696%	4166 \| 86.90%
NS5	2021	742	1995	749	1334	494	421	149	828	5771	2134	4943 \| 596%	3637 \| 63.02%
Total	22,874	4297	21,584	5020	14,348	2978	5084	1353	12,404	63,890	13,648	51,486 \| 415%	50,242 \| 78.64%

^RNumber of redundant sequences collected from the National Center for Biotechnology Information (NCBI) Taxonomy database in December 2007 [35] and April 2018
^NRNumber of non-redundant sequences after removal of duplicate sequences (full length and partial)
^aNumber and percentage of redundant sequences increase from 2007 [35] and 2018
^bNumber and percentage of sequence reduction for the 2018 dataset as a result of the removal of duplicate sequences; rounded to two decimal places

ISSN: 1471-2164