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Table 3 Nonamer positions depicting amino acid differences between an HCSS nonamer and the corresponding variants, within and between the serotypes. Only positions of mutual information value of 1 and low entropy values are shown. HCSS nonamers are shown in yellow, and one is arbitrarily chosen as the reference when more than one corresponding HCSS nonamers are present. Data for two additional positions are shown in Additional file 4: Table S4

From: Identification of highly conserved, serotype-specific dengue virus sequences: implications for vaccine design

Protein | Entropy Value

NS1 | 0.12

NS2a | 0.11

HCSS Reference

146

NRAWNSLEV

154

202

LNPTAIFLT

210

DENV1

146

Q....IW..

154

202

CK.LTM..I

210

146

Q....VW..

154

202

CK.LPM..I

210

146

L....IW..

154

202

CK.LTML.I

210

146

H....IW..

154

202

CK.LTM.FI

210

146

Q....IWK.

154

202

CK.LTMY.I

210

146

Q..S.IW..

154

202

CK.L.M..I

210

146

Q....IW.G

154

202

CK.L.ML.I

210

146

Q....I...

154

202

CK.LTM..V

210

146

Q...TIW..

154

202

CK.STM..I

210

   

202

C..LTM..I

210

   

202

SK.LTM..I

210

   

202

CK.LTMYFI

210

   

202

CKTLTM..I

210

DENV2

146

.........

154

202

 

210

146

S........

154

202

I

210

146

.......K.

154

202

S

210

146

.......KG

154

202

L

210

146

..T.D....

154

202

YF

210

146

.......KL

154

   

DENV3

146

S....VW..

154

202

VP.LPL.IF

210

146

A....VW..

154

202

VP.LPLLIF

210

146

L....VW..

154

202

IP.LPL.IF

210

146

S..L.VW..

154

202

.P.LPL.IF

210

   

202

VQ.LPL.IF

210

   

202

VS.LPL.IF

210

   

202

VP.SPL.IF

210

   

202

VPSLPL.IF

210

   

202

AQ.LPL.IF

210

DENV4

146

R........

154

202

AQALPVY.M

210

146

R....F...

154

   

146

R.....F..

154

   

146

R....FF..

154

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