Table 4 HLA-A, -B and -DR supertype-restricted T-cell epitopes, predicted for HCSS nonamers, summarised according to DENV protein and serotypes
Protein | Serotype | MHC Class I | MHC Class II | Totala | Non-redundant Totala | Totalb | Non-redundant Totala | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HLA A supertypes | HLA B supertypes | HLA DR supertypes | ||||||||||||||
A1 | A2 | A3 | B7 | B27 | B44 | B58 | B62 | Main DR | DR4 | DRB3 | ||||||
prM | DENV3 | – | – | – | – | – | – | – | – | – | 1 | – | 1 | 1 | 5 | 2 |
DENV4 | 1 | – | – | – | – | – | – | 1 | 1 | 1 | – | 4 | 1 | |||
E | DENV1 | – | – | – | – | – | – | 1 | – | – | – | – | 1 | 1 | 25 | 24 |
DENV2 | – | 1 | 2 | – | 1 | 1 | – | – | – | 1 | – | 6 | 5 | |||
DENV3 | – | – | 1 | – | – | 1 | 1 | – | – | 3 | – | 6 | 6 | |||
DENV4 | – | 2 | 2 | 1 | – | 3 | 3 | – | 1 | – | – | 12 | 12 | |||
NS1 | DENV1 | – | – | – | – | – | – | – | – | 1 | 1 | – | 2 | 1 | 14 | 13 |
DENV2 | – | – | – | – | – | – | 2 | – | – | – | – | 2 | 2 | |||
DENV3 | – | – | 1 | – | – | 1 | 1 | – | – | – | – | 3 | 3 | |||
DENV4 | – | 1 | – | 1 | 1 | 1 | 2 | 1 | – | – | – | 7 | 7 | |||
NS2a | DENV1 | – | – | – | – | – | 1 | 2 | – | – | – | – | 3 | 3 | 23 | 16 |
DENV3 | – | – | 1 | – | 1 | – | 1 | – | 3 | 3 | – | 9 | 7 | |||
DENV4 | – | – | – | 2 | 1 | – | – | – | 3 | 3 | 2 | 11 | 6 | |||
NS2b | DENV2 | – | – | 1 | – | – | – | – | – | 2 | – | – | 3 | 3 | 11 | 8 |
DENV4 | 1 | 2 | – | – | – | – | 1 | 1 | 2 | 1 | – | 8 | 5 | |||
NS3 | DENV1 | 2 | – | – | – | – | – | 2 | 2 | 1 | 1 | 2 | 10 | 6 | 36 | 28 |
DENV2 | 1 | 1 | 2 | 1 | – | 5 | – | 1 | 1 | – | – | 12 | 10 | |||
DENV3 | 1 | – | – | 1 | – | – | – | – | – | – | – | 2 | 2 | |||
DENV4 | 1 | 2 | – | 3 | – | 1 | 2 | 1 | – | 1 | 1 | 12 | 10 | |||
NS4a | DENV1 | – | – | – | 1 | – | – | – | – | – | – | – | 1 | 1 | 5 | 5 |
DENV2 | – | – | – | 1 | – | – | – | – | – | – | – | 1 | 1 | |||
DENV3 | – | – | – | – | – | 1 | – | – | – | – | – | 1 | 1 | |||
DENV4 | – | 1 | – | – | – | – | – | – | – | – | 1 | 2 | 2 | |||
NS4b | DENV1 | – | 1 | – | – | – | – | 1 | – | 1 | 1 | 1 | 5 | 3 | 23 | 13 |
DENV2 | – | 1 | – | 1 | 1 | – | 2 | 2 | 2 | 1 | – | 10 | 5 | |||
DENV3 | – | 1 | – | – | – | – | – | – | – | – | – | 1 | 1 | |||
DENV4 | – | – | 2 | – | – | – | 1 | 1 | 1 | 1 | 1 | 7 | 4 | |||
NS5 | DENV1 | 1 | – | 3 | 2 | 1 | 2 | 5 | 2 | 2 | 3 | 2 | 23 | 16 | 61 | 45 |
DENV2 | – | 1 | 2 | – | – | 1 | – | – | 1 | 1 | 2 | 8 | 7 | |||
DENV3 | 1 | 1 | 2 | – | 1 | 1 | – | – | 1 | 2 | 2 | 11 | 9 | |||
DENV4 | 1 | 1 | 2 | 1 | 1 | 2 | 5 | 3 | 1 | 1 | 1 | 19 | 13 | |||
Totalc | 10 | 16 | 21 | 15 | 8 | 21 | 32 | 15 | 24 | 26 | 15 | Â | Â | Â | 154 | |
Gene level totalc | 47 | 91 | 65 | Â | Â | Â | Â | |||||||||