Table 5 Reported epitopes that matched the predicted epitopes of HCSS sequences for structural protein E. Full data for other DENV proteins are provided in Additional file 8: Table S8
Protein | Serotype | Matched Epitopes (Starting Position | Ending Position) | HCSS Sequence | Supertype Predicted | Supertype Reported (IEDB |
|---|---|---|---|---|---|
E | DENV1 | 204|212 | 204 KSWLVHKQWFKTAHAKKQE 249 | B58 | B58: HLA-B*57:01, HLA-B*58:01 |
DENV2 | 210|218, 213|221 | 210 RQWFLDLPLPWLPG 223# | A2 | A2: HLA-A*02:06, HLA-A*02:01, HLA-A*02:17 | |
B27 | B27: HLA-B*27:05, HLA-B*48:01 | ||||
B44 | B44: HLA-B*40:01 | ||||
238|246 | 237 LVTFKNPHAKKQDVVVLGSQE 257 | A3 | A3: HLA-A*03:01, HLA-A*11:01, HLA-A*68:01 | ||
296|305, 297|305 | 281 GHLKCRLRMDKLQLKGMSYSMCTGKFK 307$ | A3 | A3: HLA-A*03:01, HLA-A*11:01, HLA-A*68:01 | ||
DENV3 | 204|212, 211|220, 212|220 | 204 KAWMVHRQWFFDLPLPW 220# | A24 | A24: HLA-A*23:01, HLA-A*24:02 | |
B44 | B44: HLA-B*44:03 | ||||
B58 | B58: HLA-B*57:01, HLA-B*58:01 | ||||
238|246 | 234 KELLVTFKNAHAKKQ 248 | A3 | A3: HLA-A*03:01, HLA-A*11:01, HLA-A*68:01 | ||
313|321 | 306 FVLKKEVSETQHGTILI 322 | B44 | B44: HLA-B*40:01, HLA-B*44:03 | ||
DENV4 | 51|59, 51|60 | 47 KTTAKEVALLRTYCIEA 63$ | B44 | B44: HLA-B*44:02, HLA-B*44:03 | |
65|73, 82|90 | 65 ISNITTATRCPTQGEPYLKEEQDQQYICRR 94# | A3 | A3: HLA-A*31:01 | ||
B44 | B44: HLA-B*40:01, HLA-B*44:03 | ||||
164|173, 165|173 | 164 ITPRSPSVEV 173# | A2 | A2: HLA-A*68:02 | ||
B7 | B7: HLA-B*07:02, HLA-B*51:01 | ||||
204|212 | 204 KTWLVHKQWF 213 | B58 | B58: HLA-B*57:01, HLA-B*58:01 | ||
237|246, 238|246, 238|247 | 235 ERMVTFKVPHAKRQDVTVLGSQEGAMHSAL 264$ | A3 | A3: HLA-A*03:01, HLA-A*11:01, HLA-A*68:01 | ||
313|321 | 290 EKLRIKGMSYTMCSGKFSIDKEMAETQHGTTVV 322 | B44 | B44: HLA-B*40:01, HLA-B*44:03 | ||
412|420 | 391 WFRKGSSIGKMFESTYRGAKRMAILGETAWDFGSVGGL 428 | B58 | B58: HLA-B*57:01, HLA-B*58:01 | ||
445|453 | 430 TSLGKAVHQVFGSVYTTMFGGVSWM 454 | B58 | B58: HLA-B*57:01, HLA-B*58:01 |