Table 6 Top 20 candidate HCSS sequence, sorted according to prioritisation criteria
Protein | Serotype | HCSS Sequence | MI Value | Entropy Value | Number of Epitopes | Number of Supertype Restrictions | Extended HLA Promiscuity | Length of HCSS Sequence |
|---|---|---|---|---|---|---|---|---|
NS2a | DENV4 | 196 TALILGAQALPVYLMTLMKGAS 217 | 1 | 0.072 | 3 | 2 | Yes | 22 |
NS2b | DENV4 | 96 TLLVKLALITVSGLYPLAIP 115 | 1 | 0.092 | 5 | 3 | No | 20 |
NS4b | DENV4 | 241 WNTTIAVSTANIFRGSY 257 | 1 | 0.168 | 2 | 2 | Yes | 17 |
NS1 | DENV4 | 34 FQPESPARLASAILNAH 50 | 1 | 0.186 | 2 | 1 | No | 17 |
NS2b | DENV2 | 31 PLVAGGLLTVCYVLTGRSADLELE 54 | 1 | 0.199 | 2 | 1 | No | 24 |
NS2a | DENV1 | 119 SLEELGDGLAMGIM 132 | 1 | 0.219 | 2 | 1 | No | 14 |
NS2b | DENV4 | 5 NEGIMAVGLVSLLGSALLKNDVPLAGPMVAGGLLLAAYVMSGS 47 | 0.999 | 0.052 | 8 | 2 | Yes | 43 |
NS5 | DENV1 | 484 LEFEALGFMNEDHWFSR 500 | 0.999 | 0.052 | 2 | 1 | No | 17 |
NS5 | DENV1 | 756 GKSYAQMWQLMYFHRRD 772 | 0.999 | 0.064 | 5 | 3 | No | 17 |
NS5 | DENV1 | 848 CGSLIGLTARATWA 861 | 0.999 | 0.066 | 2 | 1 | No | 14 |
NS3 | DENV2 | 32 GYSQIGAGVYKEGTFHTMWHVT 53 | 0.999 | 0.133 | 4 | 4 | No | 22 |
NS3 | DENV4 | 324 DPFPQSNSPIEDIEREIPERSWNTGFDWITDYQGKTVWFVP 364 | 0.999 | 0.136 | 3 | 2 | No | 41 |
NS3 | DENV2 | 78 SYGGGWKLEGEWKEGEEVQVLALEPGKNPRAVQT 111 | 0.999 | 0.189 | 2 | 1 | No | 34 |
E | DENV4 | 164 ITPRSPSVEV 173 | 0.998 | 0.155 | 2 | 2 | No | 10 |
E | DENV4 | 47 KTTAKEVALLRTYCIEA 63 | 0.997 | 0.108 | 2 | 2 | No | 17 |
E | DENV4 | 65 ISNITTATRCPTQGEPYLKEEQDQQYICRR 94 | 0.997 | 0.168 | 2 | 2 | No | 30 |
E | DENV4 | 235 ERMVTFKVPHAKRQDVTVLGSQEGAMHSAL 264 | 0.997 | 0.185 | 3 | 1 | No | 30 |
NS5 | DENV1 | 215 THEMYWVSCGTGNIVSAVNMTSRMLLNRFTM 245 | 0.996 | 0.090 | 2 | 1 | No | 31 |
NS4b | DENV2 | 207 TQVLMMRTTWALCEALT 223 | 0.996 | 0.168 | 3 | 2 | No | 17 |
NS3 | DENV1 | 546 WLSYKVASEGFQYSDRRWCFDGERNNQVLEENMDVE 581 | 0.996 | 0.178 | 2 | 1 | No | 36 |