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Table 1 GO terms identified for the differentially methylated genes (DMGs) found to differ between high motile (HM) and low motile (LM) sperm populations in gene bodies (GENE), 5′ untranslated regions (5’UTRs), 3′ untranslated regions (3’UTRs) and CpG islands (CGIs)

From: Epigenetic analysis of high and low motile sperm populations reveals methylation variation in satellite regions within the pericentromeric position and in genes functionally related to sperm DNA organization and maintenance in Bos taurus

GO-ID

GO-Term

Associated Genes Found

P-Value*

GENE

 GO:0000723

Telomere maintenance

[ERCC4, LRIG1, PRKDC, TEP1, WRN]

1.88E-02

 GO:0032200

Telomere organization

[ERCC4, LRIG1, PRKDC, TEP1, WRN]

1.92E-02

 GO:0019722

Calcium, mediated multicellular organism signaling

[ASPH, HDAC4, ITPR1, KSR2, P2RX3, PLCE1]

2.13E-02

 GO:0033555

Response to stress

[CACNA1B, GRIN2B, P2RX3]

2.46E-02

 GO:0043954

cellular component maintenance

[ABL2, MTMR2, MTSS1]

2.81E-02

 GO:0021575

Hindbrain morphogenesis

[ABL2, ATP2B2, DLC1, LDB2]

3.48E-02

 GO:0031623

Receptor internalization

[CAV3, MTMR2, PICALM]

4.76E-02

5’UTR

 GO:0010634

Positive regulation of epithelial cell migration

[BCAR1, BCAS3, ENPP2, WNT7A]

3.70E-03

 GO:0010595

Positive regulation of endothelial cell migration

[BCAR1, BCAS3, WNT7A]

5.16E-03

3’UTR

 GO:0035162

Embryonic haemopoiesis

[GATA3, KAT6A, KMT2A, PBX1, STK4]

1.31E-04

 GO:0006516

Glycoprotein catabolic process

[FBXO6, GPC1, NEU4]

4.45E-03

 GO:0046470

Phosphatidylcholine metabolic process

[LIPC, LPCAT3, PLA2G2E, SLC44A2, SLC44A4]

1.11E-02

 GO:0051569

Regulation of histone H3-K4 methylation

[AUTS2, GATA3, KMT2A]

2.37E-02

 GO:1901616

Organic hydroxy compound catabolic process

[IMPA1, LIPC, NUDT3]

2.83E-02

 GO:0042439

Ethanolamine, containing compound metabolic process

[LIPC, LPCAT3, PLA2G2E, SLC44A2, SLC44A4]

3.05E-02

 GO:0006303

Double, strand break repair via nonhomologous end joining

[KDM2A, PRPF19, WHSC1]

3.85E-02

 GO:0071353

Cellular response tointerleukin-4

[GATA3, MCM2, MCM7]

4.24E-02

 GO:0032508

DNA duplex unwinding

[FBXO18, MCM2, MCM7, MRPL36]

4.29E-02

 GO:0032392

DNA geometric change

[FBXO18, MCM2, MCM7, MRPL36]

4.31E-02

 GO:0000726

non-recombinational repair

[KDM2A, PRPF19, WHSC1]

4.97E-02

CGI

 GO:0035637

Multicellular organismal signaling

[CACNA1C, DMRT3, DPP6, KCNQ1, NFASC, P2RX3]

8.53E-04

 GO:0032288

Myelin assembly

[GPC1, NFASC, TENM4]

1.30E-03

 GO:0006942

regulation of striated muscle contraction

[CACNA1C, KCNQ1, PDE5A, TNNT3]

3.22E-03

 GO:0019226

transmission of nerve impulse

[DMRT3, DPP6, NFASC, P2RX3]

3.62E-03

 GO:0032200

Telomere organization

[ERCC4, LRIG1, TERT, WRN]

3.80E-03

 GO:0000723

Telomere maintenance

[ERCC4, LRIG1, TERT, WRN]

5.45E-03

  1. Indicated are gene ontology IDs (GO-ID), gene ontology terms (GO-term), associated genes found and corrected p-values as determined by ClueGO (http://apps.cytoscape.org/apps/cluego)
  2. * Term P-Value Corrected with Bonferroni step down