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Table 7 Gene oncology (GO) clustering analysis of differentially expressed genes1 (|fold change| > 1.3 at a false discovery rate < 0.05) in relation to lipid metabolism, energy production and oxidation resistance (n = 4)

From: Transcriptome analysis reveals mechanism underlying the differential intestinal functionality of laying hens in the late phase and peak phase of production

GO terms

GO_ID

Differentially expressed genes (fold change)

P-value

Q-value

Biological Process

 Transport

GO:0006810

FABP6 (0.58)

0.010

0.010

 Regulation of intestinal cholesterol absorption

GO:0030300

APOA1 (0.56), APOA4 (0.52)

< 0.001

0.004

 ATP synthesis coupled proton transport

GO:0015986

ATP5H (0.72), ATP5I (0.68), ATP5L (0.66)

< 0.001

0.006

 Phospholipid efflux

GO:0033700

APOA1 (0.56), APOA4 (0.52)

< 0.001

0.011

 Positive regulation of cholesterol esterification

GO:0010873

APOA1 (0.56), APOA4 (0.52)

< 0.001

0.021

 Hydrogen peroxide catabolic process

GO:0042744

PRDX1 (0.74), APOA4 (0.52)

< 0.001

0.035

 Reverse cholesterol transport

GO:0043691

APOA1 (0.56), APOA4 (0.52)

< 0.001

0.035

 Removal of superoxide radicals

GO:0019430

PRDX1 (0.74), APOA4 (0.52)

< 0.001

0.047

Cellular Component

 Mitochondrial proton-transporting ATP synthase complex

GO:0000276

ATP5H (0.72), ATP5I (0.68), ATP5L (0.66)

< 0.001

< 0.001

 Very-low density lipoprotein particle

GO:0034361

APOA1 (0.56), APOA4 (0.52)

0.001

0.035

Molecular Function

 Lipid binding

GO:0008289

FABP1 (0.38), FABP2 (0.49), FABP3 (0.41)

0.004

0.009

 Transporter activity

GO:0005215

FABP6 (0.58)

0.008

0.008

 Antioxidant activity

GO:0016209

APOA4 (0.52), FABP1 (0.38)

0.001

0.008

 Phosphatidylcholine-sterol O-acyltransferase activator activity

GO:0060228

APOA1 (0.56), APOA4 (0.52)

< 0.001

0.002

 Glutathione transferase activity

GO:0004364

GSTA3 (0.69), GSTM2 (0.59), GSTO1 (0.73)

< 0.001

0.005

 Hydrogen ion transmembrane transporter activity

GO:0015078

ATP5H (0.72), ATP5I (0.68), ATP5L (0.66)

< 0.001

0.007

 Cholesterol transporter activity

GO:0017127

APOA1 (0.56), APOA4 (0.52)

< 0.001

0.027

  1. 1FABP fatty acid-binding protein, APOA apolipoprotein A, ATP5H ATP synthase subunit d, ATP5I ATP synthase subunit e, ATP5J ATP synthase subunit f, ATP5L ATP synthase subunit g, PRDX1 peroxiredoxin-1, GSTA3 glutathione S-transferase alpha 3, GSTM2 glutathione S-transferase mu 2, GSTO1 glutathione S-transferase omega-1
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BMC Genomics

ISSN: 1471-2164

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