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Table 7 Gene oncology (GO) clustering analysis of differentially expressed genes1 (|fold change| > 1.3 at a false discovery rate < 0.05) in relation to lipid metabolism, energy production and oxidation resistance (n = 4)

From: Transcriptome analysis reveals mechanism underlying the differential intestinal functionality of laying hens in the late phase and peak phase of production

GO termsGO_IDDifferentially expressed genes (fold change)P-valueQ-value
Biological Process
 TransportGO:0006810FABP6 (0.58)0.0100.010
 Regulation of intestinal cholesterol absorptionGO:0030300APOA1 (0.56), APOA4 (0.52)< 0.0010.004
 ATP synthesis coupled proton transportGO:0015986ATP5H (0.72), ATP5I (0.68), ATP5L (0.66)< 0.0010.006
 Phospholipid effluxGO:0033700APOA1 (0.56), APOA4 (0.52)< 0.0010.011
 Positive regulation of cholesterol esterificationGO:0010873APOA1 (0.56), APOA4 (0.52)< 0.0010.021
 Hydrogen peroxide catabolic processGO:0042744PRDX1 (0.74), APOA4 (0.52)< 0.0010.035
 Reverse cholesterol transportGO:0043691APOA1 (0.56), APOA4 (0.52)< 0.0010.035
 Removal of superoxide radicalsGO:0019430PRDX1 (0.74), APOA4 (0.52)< 0.0010.047
Cellular Component
 Mitochondrial proton-transporting ATP synthase complexGO:0000276ATP5H (0.72), ATP5I (0.68), ATP5L (0.66)< 0.001< 0.001
 Very-low density lipoprotein particleGO:0034361APOA1 (0.56), APOA4 (0.52)0.0010.035
Molecular Function
 Lipid bindingGO:0008289FABP1 (0.38), FABP2 (0.49), FABP3 (0.41)0.0040.009
 Transporter activityGO:0005215FABP6 (0.58)0.0080.008
 Antioxidant activityGO:0016209APOA4 (0.52), FABP1 (0.38)0.0010.008
 Phosphatidylcholine-sterol O-acyltransferase activator activityGO:0060228APOA1 (0.56), APOA4 (0.52)< 0.0010.002
 Glutathione transferase activityGO:0004364GSTA3 (0.69), GSTM2 (0.59), GSTO1 (0.73)< 0.0010.005
 Hydrogen ion transmembrane transporter activityGO:0015078ATP5H (0.72), ATP5I (0.68), ATP5L (0.66)< 0.0010.007
 Cholesterol transporter activityGO:0017127APOA1 (0.56), APOA4 (0.52)< 0.0010.027
  1. 1FABP fatty acid-binding protein, APOA apolipoprotein A, ATP5H ATP synthase subunit d, ATP5I ATP synthase subunit e, ATP5J ATP synthase subunit f, ATP5L ATP synthase subunit g, PRDX1 peroxiredoxin-1, GSTA3 glutathione S-transferase alpha 3, GSTM2 glutathione S-transferase mu 2, GSTO1 glutathione S-transferase omega-1