Fig. 5

ApiAP2 transcription factors act as regulatory elements during gametocytogenesis. a ApiAP2 transcription factors increased in transcript abundance during gametocytogenesis were evaluated for their expression throughout gametocyte development with blocks indicating periods of increased abundance. Area plot designates the timing of appearance and abundance of specific stages throughout the time course. b The transcription factors were also probed for regulatory activity using coexpression analysis by GRENITS. Transcription factors with known binding sites [13], were probed against genes containing the transcription factor binding sites indicated or the total transcriptome if their binding site was unknown. The targets of each transcription factor are shown by shaded ribbons, with correlated transcripts indicated in red and anticorrelated transcripts indicated in blue. Newly identified motifs were associated with genes coexpressed with pf3d7_0611200 using the FIRE algorithm [54] and are indicated on the graph. Generic functional terms describing enriched gene ontology terms or individual gene products are indicated in red (increased transcripts) or blue (decreased transcripts)