Fig. 6
From: Human protein-RNA interaction network is highly stable across mammals
Heatmap showing the Human Phenotype Ontology (HPO) gene sets associated with the binding site conservation profiles of RBPs. Heatmap shows the most significant (corrected p-value < 0.05) HPO gene sets that were enriched for genes with highly conserved binding sites. Enriched HPO gene sets were identified by performing a modified gene set enrichment analysis, which uses the extent of conservation of RBP binding sites, as described in the Materials and Methods. Binding sites of NUDT21 yielded the highest number of significant HPO associations