Table 1 Mutational load of the 10 syngeneic mouse models and the corresponding human cancer (LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma)
Model | Tumor Type | Parent Strain | Origin | Mutational Load (per Mb) | Median Human Mutational Load (per Mb) |
|---|---|---|---|---|---|
4T1 | breast | BALB/c | virus | 5 | 1 |
A20 | B-cell lymphoma | BALB/c | spontaneous | 20 | NR |
CT26 | colorectal | BALB/c | carcinogen | 56 | 5 |
RENCA | renal | BALB/c | spontaneous | 46 | 1.6 |
EMT6 | breast | BALB/c | virus | 13 | 1 |
EL4 | T-cell lymphoma | C57BL/6 | carcinogen | 51 | NR |
MC38 | colorectal | C57BL/6 | carcinogen | 75 | 5 |
LLCsr | lung | C57BL/6 | spontaneous | 72 | 5.3 (LUAD) 7.5 (LUSC) |
B16F10 | melanoma | C57BL/6 | spontaneous | 35 | 9.6 |
F9 | teratocarcinoma | 129S6/SvEv | embryoimplantation | 11 | NR |