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Table 4 Melanin Biosynthesis Genes

From: Genomes and secretomes of Ascomycota fungi reveal diverse functions in plant biomass decomposition and pathogenesis

GenomeFGC_1
Aspergillus CK392
FGC_2
Coniochaeta CK134
FGC_3
Embellisia CK46
FGC_4
Chaetomium CK152
FGC_5
Phoma CK108
PKS gene cluster
Query sequences
DHN melanin biosynthesis
(A. fumigatus Af293)
DHN melanin biosynthesis (Botrytis cinerea)   
alb1(PKS)g8340.t1 (99%)g5144.t1 (60% id with Bcpks12, 46% id with Bcpks13)g6238.t1 (49% id with Bcpks12 and Bcpks13)g7880.t1 (54% id with Bpks12)g4227.t1 (49% id with Bpks12 and Bpks13, 45% id with alb1)
arp1(scytalone reductase)g8339.t1 (100%)g6728.t1 (51% id with Bcscd1 and Bcscd2, 58% id with arp1)g718.t1 (51% id with arp1, 48% id with Bscd1)g9110.t1 (54% id with Bcscd1, 58% id with arp1)g4314.t1 (48% id with Bcscd1, 53% id with arp1)
arp2 (hydroxynaphthalene reductase)g8338.t1
(100%)
g3356.t1 (55% id with B. cinerea Bcbrn1)
g9077.t1 (59% id with Bcbrn1 Condensin complex subunit 2)
g2251.t1 (78% id with Bcbrn1)
g5146.t1 (61% id with Bcbrn2 SDR)
g2727.t1 (52% id with arp2)
g2550.t1 (54% id with Bcbrn1)
g6236.t1 (69% id with Bcbrn1)
g2727.t1 (59% id with Bcbrn2)
g10828.t1 (59% id with Bcbrn1)
g11454.t1 (79% id with Bcbrn1)
g11454.t1 (50% id with arp2)
g5031.t1 (58% id with Bcbrn2)
g2131.t1 (53% id with arp2)
g1699.t1 (52% id with Bcbrn1)
g4229.t1 (70% id with Bcbrn1)
g2131.t1 (60% id with Bcbrn2)
ayg1 (conidial pigment biosynthesis protein yellowish-green1)g8337.t1
(99%)
Bcygh1 (Abhydrolase)
g5555.t1 (64%)
g10909.t1 (50% id with A. fumigatus ayg1)
g10909.t1 (54% id with Bcygh1)
g4919.t1 (60% id with Bcygh1)
g4919.t1 (50% id with ayg1)
g8790.t1 (49% id with Bcygh1)
g8790.t1 (51% id with ayg1)
abr1 (conidial pigment biosynthesis oxidase Abr1/brown 1)g8336.t1 fragment (100% id last half of query)
g8335.t1
(99%)
<  50% id<  50% id<  50% id<  50% id
abr2 (conidial pigment biosynthesis oxidase/laccase)g8334.t1 (99%)<  50% id<  50% id<  50% id<  50% id
GenomeFGC_1
Aspergillus CK392
FGC_2
Coniochaeta CK134
FGC_3
Embellisia CK46
FGC_4
Chaetomium CK152
FGC_5
Phoma CK108
GeneEumelanin biosynthesis    
Tyrosinase
1.14.18.1
g1264.t1g1168.t1
g4438.t1
g6854.t1g157.t1
g9197.t1
g5603.t1 g9014.t1 g9677.t1 g9249.t1
g145.t1
g784.t1
g2521.t1 g4858.t1 g2380.t1 g1694.t1
GenomeFGC_1
Aspergillus CK392
FGC_2
Coniochaeta CK134
FGC_3
Embellisia CK46
FGC_4
Chaetomium CK152
FGC_5
Phoma CK108
GenePyomelanin biosynthesis    
Tyrosine aminotransferase tat/ aromatic aminotransferase
2.6.1.5/2.6.1.57
g5120.t1
g776.t1
(100% id, Aspergillus fumigatus Af293)
g2830.t1
g4574.t1
(84% id, Coniochaeta ligniaria NRRL 30616)
g10171.t1
g2384.t1
(92% id, Alternaria alternata)
g10445.t1
(95% id, Colletotrichum salici
g8502.t1
(90% id, Epicoccum nigrum)
4-hydroxyphenylpyruvate dioxygenase
hppD
1.13.11.27
g986.t1
g4873.t1
g885.t1
g8201.t1
g6853.t1
g2062.t1
(Aspergillus fumigatus Af293)
g3403.t1
(80% id,
Coniochaeta ligniaria NRRL 30616)
g4879.t1
(92% id, Coniochaeta ligniaria NRRL 30616)
g5965.t1
(84% id, Alternaria alternata)g9210.t1(96% id, Alternaria alternata)
g935.t1
(80% id, Coniochaeta ligniaria NRRL 30616 g3716.t1
(87% id, Thermothelomyces thermophila ATCC 42464)
g2423.t1
(73% id, Alternaria alternata)
g7746.t1
(93% id, Ascochyta rabiei)
auto-oxidation (spontaneous oxidation in air)
step followed by polymerization into pyomelanin
+++++
  1. + Assume that this step can occur, since no enzyme is needed