Skip to main content

Table 1 A description of the function of the genes used for validation of RNAseq data

From: Genetic deletion of Sphk2 confers protection against Pseudomonas aeruginosa mediated differential expression of genes related to virulent infection and inflammation in mouse lung

Name of geneFunction of the corresponding protein
Spata13
Spermatogenesis Associated 13
Serves as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Involved in regulation of cell migration and adhesion assembly and disassembly.
Hdc
Histidine Decarboxylase
Converts L-histidine to histamine
Kdm6b
Lysine Demethylase 6B
Lysine-specific demethylase which specifically demethylates di- or tri-methylated lysine 27 of histone H3
G0 s2
G0/G1 Switch 2
Promotes apoptosis by binding to BCL2, thus preventing the formation of anti-apoptotic BCL2-BAX heterodimers
Fosl2
FOS Like 2, AP-1 Transcription Factor Subunit
The gene encodes leucine zipper proteins which can dimerize with proteins of the JUN family. Resulting in formation of the transcription factor complex AP-1. FOS proteins act as regulators of cell proliferation, differentiation, and transformation.
Dgat1
Diacylglycerol O-Acyltransferase 1
Catalyzes conversion of diacylglycerol and fatty acyl CoA to triacylglycerol
Odc1
Ornithine Decarboxylase 1
Catalyzes the first and rate-limiting step of polyamine biosynthesis converting ornithine into putrescine. Putrescine is the precursor for the polyamines which are essential for cellular processes, ranging from DNA replication to apoptosis.
Smtnl2
Smoothelin Like 2
Smoothelin is a structural protein found exclusively in contractile smooth muscle cells
Clec1a
C-Type Lectin Domain Family 1 Member A
This protein serves diverse functions, such as cell adhesion, cell-cell signaling, inflammation and immune response
Sox17
Sex Determining Region Y Box 17
Is a transcription regulator binding to target promoter DNA and bends the DNA.