Fig. 4
From: Hypothesis: protein and RNA attributes are continuously optimized over time
Age-dependent inter-species differences and post-translational modifications. a Median protein turnover of 2107 mouse and human homologs. b Median peptide turnover values of COP9 signaling complex proteins in mouse and human. c Relative human vs. mouse abundance of heat-shock proteins as determined by mass spectrometry summed peptide peaks. d Incidence of human diseases vs. ratio of human/mouse protein turnover. Blue dots: distribution of ratios of 269 orthologs. Brown dots: distribution of diseases. Brown bars: sum of diseases for bins of 30 proteins. e Median distribution of post-translational modifications in the HeLa data set. Only proteins were included that exclusively have one of the PTMs but not the others: meth. = 27, acet. = 413, phos. = 1497. f Relative fractions of acetylation (933 proteins) and phosphorylation (2699 proteins) in human HeLa data sets