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Table 1 Ranking GO categories of biological processes according to their mean protein turnover. Shown is a manually curated list of GO categories following a GO category analysis of HeLa proteins of the MS data set. Categories whose median turnover was significantly different from the overall HeLa turnover data set value (2.2) are indicated in the right column

From: Hypothesis: protein and RNA attributes are continuously optimized over time

GO CategoryBiological ProcessMean Turnover# of ProteinsDifference to total Protein Turnover
GO:0006520cellular amino acid metabolic process1.89110***
GO:0006807nitrogen compound metabolic process1.89142***
GO:0044262cellular carbohydrate metabolic process1.91108***
GO:0006631fatty acid metabolic process1.9263*
GO:0009117nucleotide metabolic process1.9384***
GO:0005975carbohydrate metabolic process1.94141***
GO:0006066alcohol metabolic process1.95107*
GO:0051186cofactor metabolic process1.9989**
GO:0006091generation of precursor metabolites and energy2.03131*
GO:0042221response to chemical stimulus2.06152 
GO:0006457protein folding2.07109 
GO:0000398nuclear mRNA splicing, via spliceosome2.08105 
GO:0006928cell motion2.0985 
GO:0051169nuclear transport2.1162 
GO:0006811ion transport2.12100 
GO:0042981regulation of apoptosis2.12185 
GO:0006396RNA processing2.17278 
GO:0007600sensory perception2.1950 
GO:0050793regulation of developmental process2.21247 
GO:0007399nervous system development2.2554 
GO:0044419interspecies interaction between organisms2.26119 
GO:0051704multi-organism process2.29140 
GO:0006955immune response2.3173 
GO:0007165signal transduction2.31556***
GO:0006281DNA repair2.32106*
GO:0009653anatomical structure morphogenesis2.38131**
GO:0010324membrane invagination2.3965***
GO:0010468regulation of gene expression2.40503***
GO:0008202steroid metabolic process2.4857***
GO:0007155cell adhesion2.50116***
GO:0007166cell surface receptor linked signal transduction2.51151**
GO:0032774RNA biosynthetic process2.5172***
GO:0048513organ development2.52126***
GO:0007275multicellular organismal development2.64111***
GO:0051301cell division2.65108***
  1. ***P < 0.001; **P < 0.01; *P < 0.05