Hypothesis: protein and RNA attributes are continuously optimized over time

Cambridge, Sidney B.

doi:10.1186/s12864-019-6371-0

BMC Genomics

Table 1 Ranking GO categories of biological processes according to their mean protein turnover. Shown is a manually curated list of GO categories following a GO category analysis of HeLa proteins of the MS data set. Categories whose median turnover was significantly different from the overall HeLa turnover data set value (2.2) are indicated in the right column

From: Hypothesis: protein and RNA attributes are continuously optimized over time

GO Category	Biological Process	Mean Turnover	# of Proteins	Difference to total Protein Turnover
GO:0006412	translation	1.82	229	***
GO:0006520	cellular amino acid metabolic process	1.89	110	***
GO:0006807	nitrogen compound metabolic process	1.89	142	***
GO:0044262	cellular carbohydrate metabolic process	1.91	108	***
GO:0006631	fatty acid metabolic process	1.92	63	*
GO:0009117	nucleotide metabolic process	1.93	84	***
GO:0005975	carbohydrate metabolic process	1.94	141	***
GO:0006066	alcohol metabolic process	1.95	107	*
GO:0051186	cofactor metabolic process	1.99	89	**
GO:0006091	generation of precursor metabolites and energy	2.03	131	*
GO:0042221	response to chemical stimulus	2.06	152
GO:0006457	protein folding	2.07	109
GO:0000398	nuclear mRNA splicing, via spliceosome	2.08	105
GO:0006928	cell motion	2.09	85
GO:0051169	nuclear transport	2.11	62
GO:0006811	ion transport	2.12	100
GO:0042981	regulation of apoptosis	2.12	185
GO:0006396	RNA processing	2.17	278
GO:0007600	sensory perception	2.19	50
GO:0050793	regulation of developmental process	2.21	247
GO:0007399	nervous system development	2.25	54
GO:0044419	interspecies interaction between organisms	2.26	119
GO:0051704	multi-organism process	2.29	140
GO:0006955	immune response	2.31	73
GO:0007165	signal transduction	2.31	556	***
GO:0006281	DNA repair	2.32	106	*
GO:0009653	anatomical structure morphogenesis	2.38	131	**
GO:0010324	membrane invagination	2.39	65	***
GO:0010468	regulation of gene expression	2.40	503	***
GO:0008202	steroid metabolic process	2.48	57	***
GO:0007155	cell adhesion	2.50	116	***
GO:0007166	cell surface receptor linked signal transduction	2.51	151	**
GO:0032774	RNA biosynthetic process	2.51	72	***
GO:0048513	organ development	2.52	126	***
GO:0007275	multicellular organismal development	2.64	111	***
GO:0051301	cell division	2.65	108	***

***P < 0.001; **P < 0.01; *P < 0.05

Back to article page

ISSN: 1471-2164

Contact us

Submission enquiries: bmcgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com