Fig. 3

The three complement pathways leading to enhanced phagocytosis of microorganisms. The binding of C3b to a receptor expressed on the surface of phagocytes and formation of the C5 convertase which generates chemotactic factors C5a and C3a, and the membrane attack complex for lysis of microbial membranes are depicted in the figure. Names of enzymatic products or complexes are shown. Common gene names are shown in boxes and are shaded in red when positively regulated in the datasets included in this study and green when negatively regulated. Each panel shows the complement pathway; however, it is superimposed with the pathway gene expression measurements for three different experimental conditions, one from each challenge category. Panel a represents the expression of the genes in the condition Diet.Fat.45.P.SI, panel b, Drug.Penicillin.SI and panel c, IC.STyph.4 day.SL1344.C. The legend shows the range of differential regulation. Complement-mediated defence mechanisms are shown in grey boxes. Modified from Microbes Online by Srijana Khanal [33]