Fig. 6

HPIs in Salmonella and E. coli involving human V-type proton ATPase subunit B (ATP6V1B2). ATP6V1B2 was involved in a total of 11 interactions with the Salmonella proteins. 10 of these interactions pertained to the flagella biosynthesis pathways in Salmonella. The HPI involving ATP6V1B2 and FliC (blue dashed arrow) was exclusive to S. enterica serovar Typhi strains (CT18 and Ty2). The remaining HPI (marked by red solid arrow) which involved EivG/ InvG (type III secretion apparatus protein) was observed in the HPI profile of all the studied Salmonella and E. coli strains except the non-pathogenic E. coli MG1655. Only two of the interactions involving flagella biosynthesis proteins (marked by solid green arrows) were seen in the HPI profiles of the pathogenic E. coli strains