Fig. 1

This schematic provides a summary of enrichment analysis results in the present study. "Infection" (Brain, Fat body, Midgut) indicates the tissue-specific comparison of genes differentially expressed as a function of aggression in the current study to genes differentially expressed as a function of infection in [18]. "Adult environment", "Predator threat", and "Behavioral maturation" indicate brain enrichment comparisons of genes differentially expressed as a funciton of aggression in the current study with a previous microarray study [3], which evaluated genes differentially expressed following exposure to aggression-inducing alarm cues (Predator threat), exposure to a high versus low aggression environment as an adult (Adult environment), and adult behavioral changes with aging (Behavioral maturation). In our data analysis, gene lists up and downregulated with infection or parasitic feeding were analyzed separately, while other aggression comparisons in the brain were analyzed irrespective of expression direction because the brain differentially expressed gene list in our study was short. Significant enrichment is indicated by a dotted circle. Gene numbers listed for each tissue sum to the total differentially expressed genes in the current study, not the total genes incorporated in the enrichment analyses; gene conversions across studies, spanning multiple genome versions, gene sets, and gene expression analysis methods, decreased the universe of genes used for enrichment analyses