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Table 4 Summary of the genome-wide significant SNPs for different CHD-related traits

From: Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci

Trait

Chr

Locus

Alleles

N per SNP

SNP(s)

P-value from FASTA, corrected with the inflation factor lambda

FHCDAE

9

31,477,907

G/A

642

BICF2G630834826

1.57 × 10–6

28

29,111,565

A/C

627

BICF2P1046032

1.62 × 10–6

OA status (binary;osteoarthritis present or not)

1

45,382,633

46,279,297

C/A

A/G

655

650

BICF2P468585

BICF2P357728

2.86 × 10–7

8.93 × 10–7

Case-control analysis (normal hips or mild-to-severe CHD; FCI scores)

1

45,382,633

45,161,186

C/A

G/C

693

693

BICF2P468585

BICF2S23248027

7.03 × 10–7

1.30 × 10–6

  1. The threshold for genome-wide significance was 1.82 × 10–6 (independent tests correction). The candidate genes in the immediate vicinity (± 200 kb) of the SNPs demonstrating genome-wide significance are in Table 5. All genes within ±1 Mb from the associated loci for all traits, for which P-value was < 1.0 × 10–5 are in Additional file 2
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BMC Genomics

ISSN: 1471-2164

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