Fig. 2

Secondary metabolite clusters with functionally characterised homologues. a The left plot shows log (fold change) expression relative to in vitro at six infection time points for genes in cluster 2_4. Light grey lines represent genes not significantly coexpressed. Coloured lines represent significantly coexpressed genes. The darker grey gene neighbours three coexpressed genes and has a similar expression pattern to them. The right plot illustrates cluster 2_4 gene arrangement. The top diagram represents Sclerotinia sclerotiorum cluster 2_4. The solid genes are conserved throughout fungi. The middle diagram is the cluster in Botrytis cinerea. Genes of the same colour are homologues of S. sclerotiorum genes. The bottom panel is the cluster in Aspergillus nidulans. Coloured genes represent homologues of the cluster and the white genes represent flanking genes. b The left plot shows the same as for A but for cluster 9_5. Lines with points are genes conserved in other fungi. Genes in this cluster were not significantly coexpressed. The right plot shows this cluster in S. sclerotiorum and B. cinerea. Non-transparent genes are in the the broadly conserved BGC, which is represented with lines and points in the expression plot to the left. Genes are coloured the same in both species if they are homologues. c The line graph is as per A but for genes in cluster 2_3. The grey lines represent genes in this cluster without significant coexpression. Coloured lines with points are significantly coexpressed genes. The right plot shows conservation of four genes within cluster 2_3. The top diagram is S. sclerotiorum, and the solid genes were significantly coexpressed. The middle diagram is B. cinerea. Genes of the same colour as the S. sclerotiorum genes are homologues. The bottom panel shows the characterised cluster in Fusarium fujikuroi, which contains homologues of four neighbouring genes sscle_02g017500-sscle_02g017530