Table 1 The 80 secondary metabolite clusters predicted in the Sclerotinia sclerotiorum genome
Name | Backbone gene type | No. genes | Up-regulated in planta | Co-expressed | Possible product |
|---|---|---|---|---|---|
01_1 | isoprenoid | 25 | yes | yes | Â |
01_2 | NRPS-like protein, PKS/NRPS-like protein | 14 | yes | no | Â |
01_3 | PKS/NRPS-like protein | 22 | yes | yes | Â |
01_4 | Type I PKS (HR), NRPS-like protein | 34 | yes | yes | Â |
01_5 | PKS/NRPS-like protein | 19 | yes | no | Â |
01_6 | Type I PKS (HR), Type I PKS (HR), PKS/NRPS-like protein | 29 | yes | yes | Â |
01_7 | Hybrid PKS-NRPS, NRPS | 12 | no | no | Â |
01_8 | NRPS-like protein, PKS/NRPS-like protein | 15 | yes | yes | Â |
02_1 | PKS/NRPS-like protein | 18 | yes | no | Â |
02_2 | PKS/NRPS-like protein | 20 | yes | yes | Â |
02_3 | PKS/NRPS-like protein | 59 | yes | yes | Carotenoid |
02_4 | PKS/NRPS-like protein, NRPS | 25 | no | no | Coprogen / fusarinine (extracellular siderophore) |
02_5 | PKS/NRPS-like protein, Hybrid PKS-NRPS | 17 | yes | no | Â |
02_6 | NRPS-like protein | 19 | yes | no | Â |
03_1 | PKS/NRPS-like protein | 9 | no | yes | Â |
03_2 | isoprenoid | 82 | no | yes | Â |
03_3 | NRPS-like protein, PKS/NRPS-like protein | 22 | yes | yes | Â |
03_4 | PKS/NRPS-like protein | 34 | no | no | Â |
03_5 | PKS/NRPS-like protein | 9 | no | no | Â |
03_6 | PKS/NRPS-like protein | 17 | no | no | Â |
03_7 | Type I PKS (NR), PKS/NRPS-like protein | 13 | no | no | dihydroxynaphthalene (DHN) melanin in appressoria |
04_1 | PKS/NRPS-like protein | 7 | no | no | Â |
04_2 | Type I PKS (HR) | 19 | no | no | Â |
04_3 | Type III PKS, Type I PKS (HR) | 28 | yes | yes | Â |
04_4 | PKS/NRPS-like protein, isoprenoid | 17 | yes | yes | Â |
04_5 | PKS/NRPS-like protein, NRPS-like protein | 65 | yes | no | Â |
04_6 | isoprenoid | 31 | no | yes | Â |
05_1 | NRPS-like protein, PKS/NRPS-like protein | 18 | no | yes | Â |
05_2 | PKS/NRPS-like protein | 13 | no | yes | Botcinic acid |
05_3 | NRPS | 27 | no | yes | Â |
05_4 | 2 x PKS/NRPS-like protein | 30 | yes | no | Â |
05_5 | isoprenoid | 36 | no | yes | Â |
05_6 | 4 x PKS/NRPS-like protein | 43 | yes | yes | Â |
05_7 | Type I PKS (NR) | 15 | yes | yes | Aromatic polyketide/Sclerotinin |
05_8 | PKS/NRPS-like protein, Type I PKS (NR) | 23 | yes | yes | Aromatic polyketide/Sclerotinin |
06_1 | PKS/NRPS-like protein | 14 | yes | yes | Â |
06_2 | NRPS-like protein | 32 | no | yes | Â |
06_3 | 2 x PKS/NRPS-like protein | 33 | yes | yes | Â |
06_4 | Type I PKS (HR) | 21 | no | yes | Â |
06_5 | other | 40 | no | yes | Â |
06_6 | other | 39 | no | yes | Â |
07_1 | Type I PKS (HR) | 29 | no | no | Â |
07_2 | NRPS-like protein, PKS/NRPS-like protein | 28 | yes | yes | Â |
07_3 | PKS/NRPS-like protein | 12 | no | no | Â |
07_4 | NRPS-like protein | 24 | yes | yes | Â |
07_5 | Type I PKS (HR), PKS/NRPS-like protein | 24 | yes | yes | Â |
07_6 | PKS/NRPS-like protein | 44 | yes | yes | Â |
08_1 | NRPS-like protein | 37 | no | yes | Â |
08_2 | PKS/NRPS-like protein | 32 | yes | no | Â |
08_3 | PKS/NRPS-like protein | 25 | no | no | Â |
09_1 | other | 14 | no | yes | Â |
09_2 | PKS/NRPS-like protein | 21 | yes | no | Â |
09_3 | PKS/NRPS-like protein, NRPS-like protein | 17 | yes | no | Â |
09_4 | PKS/NRPS-like protein | 30 | yes | yes | Â |
09_5 | NRPS | 18 | yes | no | Ferricrocin (intracellular siderophore) |
10_1 | PKS/NRPS-like protein | 12 | yes | no | Â |
10_2 | PKS/NRPS-like protein | 25 | yes | yes | Â |
10_3 | PKS/NRPS-like protein | 26 | no | yes | Â |
10_4 | PKS/NRPS-like protein | 22 | yes | no | Â |
10_5 | NRPS-like protein, NRPS | 26 | yes | yes | Epipolythiodioxopiperazine |
10_6 | PKS/NRPS-like protein | 27 | no | yes | Â |
11_1 | PKS/NRPS-like protein | 16 | no | no | Â |
11_2 | NRPS-like protein, PKS/NRPS-like protein | 38 | no | yes | Â |
11_3 | other | 40 | no | no | Â |
11_4 | NRPS-like protein | 71 | no | yes | Â |
12_1 | Type I PKS (NR) | 20 | yes | no | Sclerotial melanin |
13_1 | PKS/NRPS-like protein | 20 | yes | yes | Â |
13_2 | Type I PKS (HR) | 14 | no | no | Â |
14_1 | Hybrid PKS-NRPS (NR) | 19 | no | yes | Â |
14_2 | PKS/NRPS-like protein | 14 | no | yes | Â |
15_1 | PKS/NRPS-like protein | 30 | yes | no | Â |
15_2 | PKS/NRPS-like protein, Type I PKS (HR), NRPS-like protein | 29 | yes | no | Â |
15_3 | PKS/NRPS-like protein, Type I PKS (PR), Type I PKS (HR) | 24 | yes | yes | Botcinic acid |
15_4 | PKS/NRPS-like protein | 53 | no | yes | Â |
16_1 | NRPS-like protein | 18 | yes | yes | Â |
16_2 | isoprenoid | 38 | no | yes | Â |
16_3 | PKS/NRPS-like protein | 15 | no | no | Â |
16_4 | DMAT | 5 | no | no | Â |
16_5 | other | 20 | no | no | Â |
16_6 | PKS/NRPS-like protein | 21 | no | no | Â |