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Fig. 2 | BMC Genomics

Fig. 2

From: Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes

Fig. 2

Sampling of human PrLD sequence variants yields broad ranges of aggregation propensity scores. a Histogram indicating the frequencies corresponding to the number of unique PAPA scores per protein. b The distribution of aggregation propensity ranges, defined as the difference between the maximum and minimum aggregation propensity scores from sampled sequence variants, is indicated for all PrLDs scoring above PAPA = 0.0 and with at least one annotated sequence variant. c Histograms indicating categorical distributions of aggregation propensity scores for the theoretical minimum and maximum aggregation propensity scores attained from PrLD sequence variant sampling, as well as original aggregation propensity scores derived from the corresponding reference sequences. d Modified box plots depict the theoretical minimum and maximum PAPA scores (lower and upper bounds, respectively), along with the reference sequence score (the color transition point) for all isoforms of prototypical prion-like proteins associated with human disease

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