Fig. 3

Alternative splicing influences predicted aggregation propensity for a number of human PrLDs. a Minimum and maximum aggregation propensity scores (indicated in blue and orange respectively) are indicated for all proteins with at least one isoform below the classical PAPA = 0.05 threshold and at least one isoform above the PAPA = 0.05 threshold. For simplicity, only the highest and lowest PAPA score are indicated for each unique protein (n = 159), though many of the indicated proteins that cross the 0.05 threshold have multiple isoforms within the corresponding aggregation propensity range (n = 414 total isoforms; Additional file 2). b For all protein isoforms with an aggregation propensity score exceeding the PAPA = 0.05 threshold and with at least one higher-scoring isoform (n = 48 total isoforms, corresponding to 15 unique proteins), scores corresponding to the lower-scoring and higher-scoring isoforms are indicated in blue and orange respectively. In both panels, asterisks (*) indicate proteins for which a PrLD is also identified by PLAAC. Only isoforms for which splicing affected the PAPA score are depicted