Fig. 4

Disease-associated mutations influence predicted aggregation propensities of known PrLDs and new candidate prion-like proteins. a For all disease-associated single-amino acid substitutions that map to high-scoring PrLDs (PAPA score > 0.05) and increase predicted aggregation propensity score, scores corresponding to the wild-type and mutant sequences are indicated in blue and orange respectively. b Wild-type and mutant aggregation propensity scores are similarly plotted for all proteins with wild-type PAPA score < 0.05 but mutant PAPA score > 0.05. In both panels, asterisks (*) indicate proteins also containing a PLAAC-positive PrLD, and amino acid substitutions are indicated above each bar