Fig. 6

Gene tree for the key gene set of Notch signaling in bees. Orthologous aminoacid sequences were aligned using MAFFT, and the tree was generated using a Maximum Likelihood approach (1000 replicates). In red are the respective orthologs for F. varia. Gene names are abbreviated as: ADAM, ADAM 17-like protease; aph-1, anterior pharynx defective 1; CIR, corepressor interacting with RBPJ 1; CtBP, C-terminal binding protein; Dl, delta; Dvl, segment polarity protein dishevelled homolog DVL-3; dx, deltex; fng, fringe; gro, groucho; HATs, histone acetyltransferase KAT2A; HDAC1, histone deacetylase 1; N, notch; nct, nicastriin; numb, numb; PSE2, presenilin enhancer; Psn, presenilin; Ser, serrate; SKIP, puff-specific protein Bx42; Su(H), suppressor of hairless. Species names are given as three letter acronyms: Acer, Apis cerana; Ador, Apis dorsata; Aflo, Apis florea; Amel, Apis mellifera; Bimp, Bombus impatiens; Bter, Bombus terrestris; Dnov, Dufourea novaeangliae; Edil, Euglossa dilemma; Emex, Eufriesea mexicana; Fvar, Frieseomelitta varia; Hlab, Habropoda laboriosa; Lalb, Lasioglossum albipes; Mrot, Megachile rotundata; Mqua, Melipona quadrifasciata. Scale bars indicate the number of substitutions per site