Fig. 6

Comparison of blood stage transcriptomes from the 3D7, HB3, and IT strains of P. falciparum.a Number of transcripts with expression detected in each of the three P. falciparum strains. Detection was based on a minimum expression of 5 TPM for at least one time point within the time course. Most transcripts (78%) were detected in all three strains. b Number of transcripts with no expression detected in each of the three P. falciparum strains. Detection was based on a minimum expression of 5 TPM for at least one time point within the time course. c Expression profile of the FIKK3 gene, which shows similar timing/phase of expression in each of the three strains. d Expression profile of the ACS9 gene, which shows a different timing/phase of expression in the 3D7 strain compared to both HB3 and IT. e Identification of genes that are differentially expressed between the 3D7 strain and the HB3 strain. Coloured data points highlight genes with at least a 2 fold difference in expression and FDR < = 0.05. f Identification of genes that are differentially expressed between the 3D7 strain and the IT strain. g Identification of genes that are differentially expressed between the HB3 strain and the IT strain. h Phase (timing) differences in genes between the 3D7 strain and the HB3 strain. The mean phase difference was 0.747 rad (5.7 h). i Phase differences between the 3D7 strain and the IT strain. The mean phase difference was 0.697 rad (5.3 h). j Phase differences between the HB3 strain and the IT strain. The mean phase difference was 0.304 rad (2.3 h)