Fig. 2

Overview of significant and biologically thresholded hits across sex and time models. A) Venn diagram showing overlap of significant results (adjusted p value< 0.05) from models testing the effect of sex at T1, sex at T2, time across sexes, time in females, and time in males. B) Venn diagram showing how overlapping results shift when applying a biological threshold of delta beta > 0.05 for sex, and > 0.02 for time (i.e., reducing the model results to those meeting both significance and effect size thresholds). C) Volcano plot for sex models at T1 and T2, with effect size on the x axis and -log10 of the p value on the y axis. Significant sites with larger effects are visisble in the top left and right quadrants. D) Volcano plot for time models across sex, only females, and only males. Note. Different x axis scale for Fig. 2C and D. E) Count of adjusted p value significant probes found across models for sites that are higher in females versus higher in males. F) Count of adjusted p value significant probes meeting biological thresholds across models that are increasing or decreasing with time. Note. Different y axis scale for Fig. 2E and F