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Table 2 Differentially expressed genes in response to salinity and cold stress

From: Transcriptome analysis of the brain provides insights into the regulatory mechanism for Coilia nasus migration

Category

Gene name

Gene definition

Log2FoLdchange

P-value

Up/Down a(+/-)

Signal transduction

ADCY2

adenylate cyclase 2

1.623024029

1.69565E-06

+

 

AHNAK

Neuroblast differentiation-associated protein

1.23991252

1.8059E-05

+

 

CBLN1

Cerebellin-1

1.477382614

2.64918E-05

+

 

CARTPT

Cocaine- and amphetamine-regulated transcript protein

1.705475308

2.57562E-05

+

 

EPHA4

Eph receptor A4

2.789583201

1.35975E-06

+

 

GRIN2A

glutamate receptor ionotropic, NMDA 2A

1.857980995

3.70302E-05

+

 

GRIA1

glutamate receptor 1

1.688055994

3.12289E-05

+

 

GRM5

metabotropic glutamate receptor 5

2.364836686

3.71795E-06

+

 

GABRD

gmma-aminobutyric acid receptor subunit gamma

5.95631015

9.03684E-16

+

 

GAL

Galanin peptide

27.63200829

4.90E-12

+

 

GALR1/R2

galanin receptor 1

2.606657572

4.26707E-05

+

 

GLDN

Gliomedin

2.294447358

5.23949E-06

+

 

GNG2

guanine nucleotide-binding protein G (I)/G (S)/G (O) subunit gamma-2

4.727920455

5.78933E-06

+

 

GNGT1

guanine nucleotide-binding protein G (T) subunit gamma-T1

7.078259014

6.39E-10

+

 

HTR4

5-hydroxytryptamine receptor 4

3.754887502

1.50417E-05

+

 

LRRTM4

Leucine-rich repeat transmembrane neuronal protein 4

2.331514144

1.57678E-05

+

 

MCH2

Pro-MCH 2

25.97596269

2.10002E-07

+

 

NCS1

Neuronal calcium sensor 1

2.047305715

1.22204E-05

+

 

NPBWR2

neuropeptides B/W receptor 2

4.054765803

2.71068E-09

+

 

NPY

neuropeptide Y

1.627628966

2.82109E-06

+

 

NSG1

Neuron-specific protein family member 1

1.047174058

4.29656E-05

+

 

NTSR1

Neurotensin receptor type 1

3.137503524

1.05811E-05

+

 

OPRL1

nociceptin receptor

1.521397372

3.59681E-05

+

 

PENKB

proenkephalin B (prodynorphin)

3.242856524

1.6675E-07

+

 

PNOC

Prepronociceptin

2.532269607

4.4328E-07

+

 

RIMS

regulating synaptic membrane exocytosis protein

1.002266607

2.38297E-05

+

 

SIPA1L1

signal-induced proliferation-associated 1 like protein 1

2.019469864

5.7446E-06

+

 

SV2

MFS transporter, VNT family, synaptic vesicle glycoprotein 2

1.105773138

3.32163E-05

+

 

SLC18A1_2

MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2

5.129283017

1.5945E-05

+

 

SLC1A

solute carrier family 1 (glutamate transporter), member 7

4.169925001

2.75989E-05

+

 

SLC6A1

solute carrier family 6 (neurotransmitter transporter, GABA) member 1

-1.795641501

3.94984E-05

 

–

SNAP25

synaptosomal-associated protein 25

5.087462841

1.77515E-05

+

 

STAT

signal transducer and activator of transcription

2.359895945

4.93096E-05

+

 

SYNPR

Synaptoporin

5.087462841

5.35768E-08

+

 

SYT1/10

synaptotagmin-1

1.503662399

2.83789E-05

+

 

TAAR

trace amine associated receptor

3.5698751

2.98658E-05

+

 

TAC1

tachykinin 1

2.510961919

3.78253E-06

+

 

TENM1

Teneurin-1

2.895530733

8.37792E-07

+

 

OPRL1

Nociceptin receptor

1.521397372

3.59681E-05

+

 

Sensory system

AIPL1

Aryl-hydrocarbon-interacting protein-like 1

6.087462841

1.07977E-08

+

 

ANO7

Anoctamin -7

1.179072643

1.89574E-05

+

 

AVPR1B

Vasopressin V1b receptor

24.45513053

2.58472E-05

+

 

CLDN

Claudin-22

3.896164189

6.32318E-07

+

 

CNGA2/CNGB1

cyclic nucleotide gated channel alpha 2/beta 1

17.93156857

1.96876E-05

+

 

CRYAB

crystallin, alpha B

1.201986211

1.9046E-05

+

 

EYA4

Eyes absent homolog 4

-2.411813598

1.34683E-05

 

–

GABRB

gamma-aminobutyric acid receptor subunit beta

3.005805622

6.20322E-07

+

 

GNAT1_2

guanine nucleotide-binding protein G (t) subunit alpha 1/2

-4.727920455

5.78933E-06

 

–

GPRC5C

G-protein coupled receptor family C group 5 member C

25.21697079

3.47461E-06

+

 

GUCA1

guanylate cyclase activator 1

5.673002535

9.35629E-07

+

 

LRAT

phosphatidylcholine-retinol O-acyltransferase

25.95393638

2.31133E-07

+

 

LXN

Latexin

-1.459431619

5.90012E-06

 

–

NCKX1

solute carrier family 24 (sodium/potassium/calcium exchanger), member 1

3.554588852

2.60147E-05

 

–

PDE1

calcium/calmodulin-dependent 3’,5’-cyclic nucleotide phosphodiesterase

1.58282359

1.02849E-05

+

 

PDE6A/6B

rod cGMP-specific 3’,5’-cyclic phosphodiesterase subunit alpha/beta

-5.882643049

1.50714E-06

 

–

RCVRN

recoverin

-1.734266445

1.66801E-05

 

–

RGR

RPE-retinal G protein-coupled receptor

3.022367813

2.50182E-05

+

 

RHO

rhodopsin

-5.736965594

1.46417E-11

 

–

RLBP1

Retinaldehyde-binding protein 1

-3.594181031

6.71346E-07

 

–

RP1L1

Retinitis pigmentosa 1-like 1 protein

1.834221528

1.9372E-05

+

 

RPE65

retinoid isomerohydrolase

2.777607579

4.71976E-07

+

 

STRC

Stereocilin

-3.222392421

2.61719E-05

 

–

TAS1R1

taste receptor type 1 member 1

-3.544320516

4.83161E-05

 

–

TBR1

T-box brain protein 1

30.21465692

3.06E-28

+

 

TECTA

Alpha-tectorin

-2.725283789

2.72437E-06

 

–

TMC2

Transmembrane channel-like protein 2

3.896164189

6.32318E-07

+

 

TRPC3

Short transient receptor potential channel 3

-4.85077616

5.48984E-26

 

–

VAX1

Ventral anterior homeobox 1

25.21697079

3.47461E-06

+

 

Stress response

AHCY

adenosylhomocysteinase

-3.689214537

1.72215E-05

 

–

AMD1

S-adenosylmethionine decarboxylase

-2.136372442

3.90066E-06

 

–

AQP9

aquaporin-4

4.882643049

3.44583E-06

+

 

ATP1B

sodium/potassium-transporting ATPase subunit beta

-1.026216857

1.43307E-05

 

–

CLDN

claudin

3.896164189

6.32318E-07

+

 

CYP51

sterol 14-demethylase

4.24879339

4.57294E-05

+

 

GHRH

Somatoliberin

4.307428525

9.87095E-07

+

 

HP

Haptoglobin

2.797137522

6.13977E-08

+

 

HSP70

Heat shock protein 70

1.985378817

6.00422E-08

+

 

METE

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

5.459431619

1.97921E-06

+

 

METK

S-adenosylmethionine synthetase

4.64385619

1.96876E-05

+

 

MTHFD

methylenetetrahydrofolate dehydrogenase

1.949534933

1.07109E-05

+

 

NTS

Neurotensin

5.544320516

9.11866E-11

+

 

PRLR

prolactin receptor

1.870147682

2.42871E-05

+

 

SLC6A5

Sodium- and chloride-dependent glycine transporter 2

3.440566897

1.10089E-06

+

 

SSTR1

somatostatin receptor 1

4.247927513

2.91451E-06

+

 

TACR3

tachykinin receptor 3

-2.473931188

1.14954E-05

+

 

TRPC3

Short transient receptor potential channel 3

-5.48984E-26

1.9283E-24

 

–

RGS9

regulator of G-protein signaling 9

1.205267382

2.78147E-05

+

 

PRDX1/6

peroxiredoxin 6, 1-Cys peroxiredoxin

24.93156857

7.99857E-06

+

 

ATP1A/1B

sodium/potassium-transporting ATPase subunit alpha/beta

5.977279923

2.8038E-07

+

 

CACNB4/CACNG4

voltage-dependent calcium channel beta-4/gamma-4

1.086335169

4.49908E-05

+

 

CADPS2

Calcium-dependent secretion activator 2

3.736965594

3.10145E-05

+

 

CORIN

Atrial natriuretic peptide-converting enzyme

1.595769256

2.17862E-05

+

 

GRIK1

glutamate receptor, ionotropic kainate 1

1.857980995

3.70302E-05

+

 

KCNA10

Potassium voltage-gated channel subfamily A member 10

2.475733431

1.21502E-06

+

 

KCNE1

potassium voltage-gated channel Isk-related subfamily E member 1

4.794415866

2.64187E-07

+

 

KCNIP1

Kv channel-interacting protein 1

1.478302393

3.18614E-05

+

 

KCNJ3

potassium inwardly-rectifying channel subfamily J member 3

1.538699778

1.97736E-05

+

 

KCNQ1

potassium voltage-gated channel KQT-like subfamily member 1

3.938599142

3.938599142

+

 

SCN4AB

Sodium channel protein type 4 subunit alpha B

4.266786541

6.43397E-12

+

 
  1. aUp/Down: DEGs upregulated or downregulated compared to the control group
  2. Upregulated DEGs were those with log2Foldchange > 0, and downregulated DEGs were those with log2Foldchange < 0