Table 3 MSDIN family members cloned from genomic DNA of twelve amanitin-producing mushrooms

A. exitialis

Ae1^a

MSDINATRLP

FIWVFGIP

GDIGTVLTRGENLC*

MN318165

Ae2^a

MSDINATRLP

IIWIIGNP

CVSDDVERILTRGESLC*

MN318166

Ae3^ab

MSDINATRLP

IWGIGCDP

CVGDDVTALLTRGEALC*

β-amanitin

MN264225

Ae4^ab

MSDINATRLP

IWGIGCNP

CVGDDVTSVLTRGEALC*

α-amanitin

MN264220

Ae5^b

MSDINATRLP

AWLTDCP

CVGDDVNRLLTRGESLC*

“phallotoxin”

MN264235

Ae6^b

MSDINATRLP

AWLVDCP

CVGDDVNRLLTRGESLC*

phallacidin

MN264231

Ae7^a

MSDINATRLP

VWIGYSP

CVGDDCIALLTRGEGLC*

MN318167

Ae8^a

MSDINATRLP

GFLFWA

YVGDDVDYILTRGESLA*

MN318168

Ae9^a

MSDINATRLP

GFLLWA

YVGDDVDYILTRGESLA*

MN318169

A. fuliginea

Af1^a

MSDINATRLP

FPHFPPYNPP

CVSDDIHMVLTRGENLC*

MN318170

Af2^a

MSDINATRLP

YYLLLILPP

CVSDDLQTVLTRGENLC*

MN318171

Af3^a

MSDINATRLP

IFWFIYFP

CVGDDVDNTLARGESLS*

MN318172

Af4^b

MSDINATRLP

IWGIGCDP

CVGDDVAALITRGEALC*

β-amanitin

MN264226

Af5^a

MSDINATRLP

IWGIGCDP

CVGEDVAALITRGEALC*

β-amanitin

MN318173

Af6^a

MSDINATRLP

IWGIGCNP

SVGDEVTALLTSGEALC*

α-amanitin

MN318174

Af7^a

MSDINATRLP

LPSRPVFP

FVSDAIEVVLGRGEDLC*

MN318175

Af8^b

MSDINASRLP

AWLATCP

CIGDDVNPTITRGESLC*

phalloidin

MN264249

Af9^ab

MSDINATRLP

AWLVDCP

CVGDDVNRLLARGENLC*

phallacidin

MN264232

A. molliuscula

Am1^b

MSDINATRLA

IWGIGCDP

CVGDDVTALLTRGEALC*

β-amanitin

MN264227

A. pallidorosea

Ap1^a

MSDINATRLP

LIFIPPFIPP

CVSDDIQMVLTRGENLC*

MN318176

Ap2^a

MSDINAPRLP

LIFIPPFIPP

CVSDDIQMVLTRGEGLC*

MN318177

Ap3^a

MSDINATRLP

IPFHIPAP

SVGDDIEVVLGRGENLC*

MN318178

Ap4^a

MSDINATRLP

IWGIGCDP

CVGDDVTAVLTCGEALC*

β-amanitin

MN318179

Ap5^b

MSDINATRLP

IWGIGCDP

CVGDDVTAVLTRGEALC*

β-amanitin

MN264228

Ap6^ab

MSDINATRLP

IWGIGCNP

CVGDEVAALLTRGEALC*

α-amanitin

MN264222

Ap7^b

MSDINATRLP

IWGIGCNP

CVGDEVTALITRGEALC*

α-amanitin

MN264221

Ap8^a

MSDINATRLP

AWLATCP

CAGDDVNPTLTRGESLC*

phalloidin

MN318180

Ap9^a

MSDINATRLP

AWLMTCP

CVGDDVNPILTRGESVC*

“phallotoxin”

MN318181

Ap10^b

MSDINATRLP

AWLMTCP

CVGDDVNPTLTRGESLC*

“phallotoxin”

MN264236

Ap11^ab

MSDVNATRLP

AWLVDCP

CVGDDINRLLTRGENLC*

phallacidin

MN264233

A. rimosa

Ar1^a

MSDINATRLP

IWGIGCDP

CVGDDVAALATRGEALC*

β-amanitin

MN318182

Ar2^ab

MSDINATRLP

IWGIGCDP

CVGDDVAALTTRGEALC*

β-amanitin

MN264229

Ar3^a

MSDINATRLP

IWGIGCNP

SVGDEVTALLASGEALC*

α-amanitin

MN318183

Ar4^ab

MSDINSTRLP

IWGIGCNP

SVGDEVTALLTRGEALC*

α-amanitin

MN264223

Ar5^b

MSDINATRVP

AWLAECP

CVGDDISHLLTRGENLC*

“phallotoxin”

MN264237

A. subfuliginea

Asf1^a

MSDINATRLP

HPFPLGLQP

CAGDVDNFTLTKGEGLC*

MN318184

Asf2^a

MSDINATRLP

AIFLAWPP

CVGDNVNSTLTRGESLC*

MN318185

Asf3^a

MSDINATRLP

IWGIGCDP

CVSDDVAALLTRGEALC*

β-amanitin

MN318186

Asf4^a

MSDINATRLP

IWGIGCNP

CVGDEVAALLTRGEALC*

α-amanitin

MN318187

Asf5^a

MSDINATRLP

AWLVDCP

CVGDDVNRLITRGENLC*

phallacidin

MN318188

A. subjunquillea

Asj1^a

MSDINATRLP

AYLPLFFIPP

CVSDDIEMVLTRGESLC*

MN318189

Asj2^a

MSDINATRLP

AYLPLFFIPP

CVSDDIEVVLTRGESLC*

MN318190

Asj3^a

MSDINATRLP

IWGIGCDP

CIGDDVTALLTRGEALC*

β-amanitin

MH142177

Asj4^a

MSDINATRLP

IWGIGCDP

CVGDEVTALLTRGEALC*

β-amanitin

MH142176

Asj5^a

MSDINATRLP

IWGIGCNP

CVGDEVAALLTRGEALC*

α-amanitin

MH142175

Asj6^ab

MSDINATRLP

AWLATCP

CAGDDVNPTLTRGESLC*

phalloidin

MN264250

Asj7^a

MSDINATRLP

AWLATCP

CVGDDVNPTLSRGESLC*

phalloidin

MN318191

Asj8^ab

MSDINATRLP

AWLVDCP

CVGDDINRLLTRGENLC*

phallacidin

MN264234

A. subpallidorosea

Asp1^ab

MSDINATRLP

IWGIGCDP

CVGDDVAAFLTRGEALC*

β-amanitin

MN264230

Asp2^ab

MSDINATRLP

IWGIGCNP

SVGDEVTALLTRGEALC*

α-amanitin

MN264224

Asp3^ab

MSDINAARLP

AWITDCP

CVGDDINRILTRGENIC*

“phallotoxin”

MN272408

Asp4^ab

MSDINASRFP

AWLATCP

CVGDDVNPTIARGESLC*

phalloidin

MN272407

Asp5^a

MSDINATRLP

AWLITCP

CVGDDANPTITRGESLC*

“phallotoxin”

MN318192

Asp6^ab

MSDINATRLP

AWLVTCP

CVGDDVNPTITRGESLC*

“phallotoxin”

MN272409

Asp7^a

MSDINATRLP

AWLVTCP

CVGDDVNSTITRGESLC*

“phallotoxin”

MN318193

A. virosa

Av1^a

MSDINATRLP

FLLFIIPP

CVSDDVNSTLTRGESLC*

MN318194

Av2^a

MSDINATRLP

FYFQPGFP

WSVGDDVNPTLTRGESLC*

MN318195

Av3^b

MSDINATRLP

IWGIGCNP

SVGDEATALLTRGEALC*

α-amanitin

MN272412

Av4^a

MSDINATRLP

SILIVWPP

CVGDDVNSTLTRGESLC*

MN318196

Av5^a

MSDINATRLP

SILVVWPP

CVSDDVNSTLTRGESLC*

MN318197

Av6^a

MSDINATRLP

AWLATCP

CVGDDVNPTLARGESLC*

phalloidin

MN318198

Av7^a

MSDINATRLP

AWLVDCP

CVGDDINRLLTRGENLC*

phallacidin

MN318199

Av8^a

MSDINATRLP

AWLVTCP

CVGDDVNPTLTRGESLC*

“phallotoxin”

MN318200

Av9^a

MSDINATRLP

GPFLFFP

FVSDDIEVILRRGEDLC*

MN318201

G. marginata

Gm1^b

MFDTNATRLP

IWGIGCNP

WTAEHVDQTLASGNDIC*

α-amanitin

MN272413

Gm2^b

MFDTNSTRLP

IWGIGCNP

WTAEHVDQTLVSGNDIC*

α-amanitin

MN272414

G. sulciceps

Gs1^b

MFDTNATRLP

IWGIGCNP

WTAEHVDQTLASGNDIC*

α-amanitin

MN272417

Gs2^b

MFDTNSTRLP

I*GIGCNP

WTAEHIDQTLVSGNDTC*

MN272418

L. venenata

Lv1^b

MDANATRLP

IWGIGCNP

WTPESVNDTLTKDLS

α-amanitin

MN272421

Lv2^b

MDANSTRLP

IWGIGCNP

WAPESVNDTLTRGKDLC

α-amanitin

MN272422