Fig. 5

Summary of IPA results based on the 397 highly concordant orthologous genes. a, b Top Biofunctions and the most significantly enriched Canonical Pathways identified by IPA. Bars represent the number of genes in the functional category or the canonical pathway (primary y-axis) and the orange line represents the significance of the category or the pathway in -Log(p-value) (secondary y-axis). c Upstream regulators that target a significant portion of the genes in the input list. The inferred activation states of the regulators based on the observed expression of their targets are noted (e.g. an increased expression in targets that are induced by a regulator may imply an “activated” state for the regulator). N/A implies an inconclusive activation state of the regulator. d Number of genes and emerging biological functions in the deduced interaction networks that involve input genes. e Sets of regulators with a combined target gene set that show concordant enrichment in biological functions. Bars represent the total number of genes targeted by each set of regulators. On each bar, the biological functions that are significantly enriched by the target genes are noted