Table 1 KEGG pathway enrichment for the DEGs between S-27, S-39, and CK
KEGG pathway | Log10[FDR corrected q-value] | DEGs | ||||
|---|---|---|---|---|---|---|
S-27 vs CK | S-39 vs CK | S-27 vs S-39 | S-27 vs CK | S-39 vs CK | S-27 vs S-39 | |
Longevity regulating pathway - multiple species | −20.76 | −8.46 | ns | HSPA70, CRYAB | HSP70, CRYAB, ADCY5, INSR, RPS6KB | 0 |
Protein processing in endoplasmic reticulum | −15.08 | −6.74 | ns | HSPA70, CRYAB | HSP70, CRYAB, HSPBP1, PREB, DNAJC3, BCAP31, HSP90A, UBE2G2, UBC7, UBE4B | 0 |
Antigen processing and presentation | −12.38 | −5.31 | ns | HSPA70, NFYA | HSP70, CTSL, HSP90A | 0 |
MAPK signaling pathway | −10.75 | −2.27 | ns | HSP70, HSP27, MEF2C, PPP5C, FGF | HSP70, HSP27, MEF2C, PAK1, SRF | 0 |
Legionellosis | −10.75 | −2.96 | ns | HSP70 | HSP70, CASP7 | 0 |
Toxoplasmosis | −10.40 | −2.81 | ns | HSP70 | HSP70, ITGB1 | 0 |
Measles | −10.34 | −2.77 | ns | HSP70 | HSP70, GSK3B | 0 |
Epstein-Barr virus infection | −9.20 | −2.81 | ns | HSP70, HSP27 | HSP70, HSP27, EP300, RPB1, GSK3B | 0 |
Influenza A | −8.12 | −1.61 | ns | HSP70, UAP56, HNRNPUL1 | HSP70, EP300, NS1BP, DNAJC3, GSK3B | 0 |
Estrogen signaling pathway | −7.81 | −2.85 | ns | HSP70 | HSP70, ADCY5, FKBP4_5, HSP90A, CALM | 0 |
Spliceosome | −7.39 | ns | ns | HSP70, DHX38, UAP56, SYF1 | 0 | 0 |
Endocytosis | −5.32 | −1.57 | ns | HSP70 | HSP70, CBL, ASAP, EHD3, CHMP2B, USP8, UBP5, ARFGEF, BIG | 0 |
Biosynthesis of unsaturated fatty acids | ns | −1.84 | ns | 0 | HADHA, PHS1, ACOX1, SCD | 0 |
Retinol metabolism | ns | ns | −2.76 | 0 | 0 | UGT, SDR16C5, RDH12 |
Porphyrin and chlorophyll metabolism | ns | ns | −2.57 | 0 | 0 | HCCS, UGT, hemH |
Ascorbate and aldarate metabolism | ns | ns | −1.65 | 0 | 0 | GNL,UGT |
Drug metabolism - cytochrome P450 | ns | ns | −1.65 | 0 | 0 | UGT, GST |
Drug metabolism - other enzymes | ns | ns | −1.65 | 0 | 0 | UPB1, DPYD, UGT |
Metabolism of xenobiotics by cytochrome P450 | ns | ns | −1.65 | 0 | 0 | UGT, GST, EPHX1 |
Steroid hormone biosynthesis | ns | ns | −1.60 | 0 | 0 | UGT |