Fig. 1

TO-GCN with 9 levels was constructed from 1191 TF genes. FOSL1, a TF with the strongest monotonic descending pattern (DE = 0), was used as initial TF gene. All TFs were linked together by co-expression relationship (gray line), while some of the co-expression were reported with TRR database support (blue line). TF coloured with green and purple are the TF genes with DE ≤ 4 in descending and ascending pattern respectively. The numbers stated in the middle of each level represent the number of TFs, and TFs with DE ≤ 4 (in parentheses) for that particular level