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Fig. 4 | BMC Genomics

Fig. 4

From: Genome-wide association analysis of canine T zone lymphoma identifies link to hypothyroidism and a shared association with mast-cell tumors

Fig. 4

Close-up of the chromosome 14 peak depicting change in signal with MCT dataset added. a TZL dataset only. b Combined TZL and MCT dataset; c Close-up of the region from 8-12Mbp containing SNPs with R2 > 0.2. d Close-up view of genes located in the region from 11 to 12 Mb. The four SNPs significantly associated with TZL are depicted in red and the nine-SNP haplotype block they represent is shaded in yellow. e Close-up of the region from 11.7–11.8 Mbp where coding mutations (shown in red) were found on resequencing. f Haplotype block containing nine associated SNPs on cfa14 (BICF2G630521558, BICF2G630521572, BICF2G630521606, BICF2G630521619, BICF2P867665, TIGRP2P186605, BICF2G630521678, BICF2G630521681, BICF2G630521696). The risk haplotype was CTTCGGACG and non-risk was TCCTTAGTA. Dogs were considered recombined if neither combination was present and were considered unknown if the genotype for one or more SNPs was missing

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