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Table 1 SNPs significantly associated with TZL at the genome-wide level

From: Genome-wide association analysis of canine T zone lymphoma identifies link to hypothyroidism and a shared association with mast-cell tumors

SNP

Chr

BP

Alleles

Associated Allele Frequency

R2 from top SNP

GWAS results

Conditional GWAS with Chr8 top SNP

Conditional GWAS with Chr14 top SNP

TZL

Ref

OR

P-value

OR

P-value

OR

P-value

BICF2S23237035

2

77,686,623

T/C

0.11

0.05

 

1.41

6.21E-05

    

BICF2P1011303

8

52,650,576

T/C

0.18

0.07

0.53

1.30

4.60E-05

1.03

0.663

  

BICF2P29000

8

52,763,337

C/A

0.25

0.12

0.28

1.24

7.46E-05

1.07

0.170

  

BICF2P378684

8

53,742,667

C/T

0.15

0.04

0.59

1.42

5.71E-06

1.04

0.560

  

BICF2P1080535

8

53,778,185

T/C

0.16

0.05

0.75

1.36

1.50E-05

0.99

0.935

  

BICF2P1048848

8

53,785,948

A/G

0.16

0.05

0.75

1.36

1.50E-05

0.99

0.935

  

BICF2P184533

8

53,796,442

G/A

0.16

0.06

0.79

1.37

7.36E-06

1.00

0.978

  

BICF2P948919

8

53,818,371

G/A

0.21

0.07

1.00

1.39

2.66E-07

1.00

1.000

  

TIGRP2P186605

14

11,778,977

G/A

0.66

0.43

0.93

1.18

5.13E-05

  

1.00

0.995

BICF2G630521678

14

11,791,385

A/G

0.67

0.43

0.99

1.18

3.00E-05

  

1.00

0.966

BICF2G630521681

14

11,794,735

C/T

0.67

0.43

1.00

1.19

2.28E-05

  

1.00

1.000

BICF2G630521696

14

11,807,161

G/A

0.67

0.43

0.99

1.18

3.67E-05

  

1.00

0.934

BICF2S23029378

17

4,217,272

G/A

0.88

0.73

 

1.19

9.47E-05

    

BICF2G630222435

17

8,102,574

T/G

0.83

0.64

 

1.18

8.66E-05

    

BICF2P916139

17

8,135,932

T/A

0.82

0.63

 

1.18

8.39E-05

    

BICF2G630221951

17

8,819,612

C/T

0.85

0.65

 

1.19

9.42E-05

    

BICF2P780894

29

10,587,617

G/A

0.63

0.46

 

1.18

7.45E-05

    
  1. The top SNPs (smallest p-value) for the chromosome 8 and 14 peaks are bolded. Ref represents the combined TZUS and control reference group