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Table 2 The enrichment of DEGs in GO terms for down-regulated genes in GNRH1 treated hens compared to AVT hens

From: Transcriptome analysis of the uterus of hens laying eggs differing in cuticle deposition

Category GO ID and term Count P-value Genes
Biological process ontology 0043618: regulation of transcription from RNA polymerase II promoter in response to stress 3 1.30E-04 KLF2, JUN, ATF3
0070372: regulation of ERK1 and ERK2 cascade 6 8.16E-06 CYR61, CCAH221, SLC30A10, SPRY2, JUN, ATF3
0006469: negative regulation of protein kinase activity 5 2.00E-04 SOCS1, DUSP8, DUSP6, SPRY2, ERRFI2
0009888: tissue development 13 2.57E-06 HBEGF, NEXN, TXK, CYR61, TIPARP, FOS, SPRY2, KLF2, JUN, ATF3, ARC, NR4A3, ERRFI2
1901700: response to oxygen-containing compound 9 1.07E-04 KCNJ11, SOCS1, FOS, TNFRSF6B, SLC30A10, HSP70, JUN, NR4A3, PDK4
0009605: response to external stimulus 13 3.47E-06 HBEGF, CH25H, KCNJ11, CCAH221, ZC3HAV1, FOS, TNFRSF6B, JUN, ATF3, PENK, NR4A3, PDK4, TLR15
0042981: regulation of apoptotic process 10 2.36E-04 CYR61, HNRNPU, TNFRSF6B, SLC30A10, SPRY2, JUN, PDILT, ATF3, NR4A3, PDK4
0032879: regulation of localization 16 1.18E-05 HBEGF, NEXN, PCDH17, KCNJ11, CYR61, SS2, SOCS1, POMC, SLC30A10, SPRY2, HSP70, JUN, CEMIP, NR4A3, TLR15, RRAD
0070887: cellular response to chemical stimulus 14 6.85E-05 HBEGF, CH25H, TIPARP, SOCS1, CCAH221, FOS, TNFRSF6B, SLC30A10, SPRY2, JUN, ATF3, ETV5, NR4A3, PDK4
0010033: response to organic substance 14 7.43E-05 KCNJ11, TIPARP, SOCS1, CCAH221, FOS, TNFRSF6B, SLC30A10, SPRY2, HSP70, JUN, ATF3, NR4A3, PDK4, TLR15
0051173: positive regulation of nitrogen compound metabolic process 17 1.72E-05 HBEGF, EGR4, TXK, CYR61, TIPARP, CCAH221, ZC3HAV1, FOS, SLC30A10, SPRY2, KLF2, HSP70, JUN, ATF3, ETV5, CEMIP, NR4A3
0030154: cell differentiation 19 5.89E-06 NEXN, TXK, CYR61, TIPARP, GRN, SOCS1, FOS, CHAC1, SPRY2, KLF2, HSP70, JUN, PDILT, ATF3, ETV5, NR4A3, NYAP2, NPTX1, MYCL
0010604: positive regulation of macromolecule metabolic process 17 2.74E-05 HBEGF, EGR4, TXK, CYR61, TIPARP, CCAH221, ZC3HAV1, FOS, SLC30A10, SPRY2, KLF2, HSP70, JUN, ATF3, ETV5, CEMIP, NR4A3
0031325: positive regulation of cellular metabolic process 16 1.15E-04 HBEGF, EGR4, TXK, CYR61, CCAH221, ZC3HAV1, FOS, SLC30A10, SPRY2, KLF2, HSP70, JUN, ATF3, ETV5, CEMIP, NR4A3
0048731: system development 19 6.46E-05 HBEGF, NEXN, PCDH17, CYR61, TIPARP, HNRNPU, PAPSS2, FOS, CHAC1, SPRY2, KLF2, JUN, ATF3, NR4A3, HNRNPU, NPTX1, MYCL, NPY5R, ERRFI1
0007165: signal transduction 26 4.49E-06 HBEGF, MCHR2, TXK, CYR61, SS2, TIPARP, SOCS1, LOC422147, CCAH221, RGS1, FOS, TNFRSF6B, POMC, SLC30A10, CHAC1, JUN, ATF3, PENK, NR4A3, NYAP2, GNG4, PDK4, RCAN1, NPY5R, TLR15, RRAD
Molecular function ontology 0005539: glycosaminoglycan binding 6 2.83E-06 HBEGF, CYR61, THBS1, CEMIP, SPP1, REG4
Cellular component ontology  
0010033: response to organic substance 14 7.43E-05 KCNJ11, TIPARP, SOCS1, CCAH221, FOS, TNFRSF6B, SLC30A10, SPRY2, HSP70, JUN, ATF3, NR4A3, PDK4, TLR15
0051173: positive regulation of nitrogen compound metabolic process 17 1.72E-05 HBEGF, EGR4, TXK, CYR61, TIPARP, CCAH221, ZC3HAV1, FOS, SLC30A10, SPRY2, KLF2, HSP70, JUN, ATF3, ETV5, CEMIP, NR4A3
0030154: cell differentiation 19 5.89E-06 NEXN, TXK, CYR61, TIPARP, GRN, SOCS1, FOS, CHAC1, SPRY2, KLF2, HSP70, JUN, PDILT, ATF3, ETV5, NR4A3, NYAP2, NPTX1, MYCL
0010604: positive regulation of macromolecule metabolic process 17 2.74E-05 HBEGF, EGR4, TXK, CYR61, TIPARP, CCAH221, ZC3HAV1, FOS, SLC30A10, SPRY2, KLF2, HSP70, JUN, ATF3, ETV5, CEMIP, NR4A3
0031325: positive regulation of cellular metabolic process 16 1.15E-04 HBEGF, EGR4, TXK, CYR61, CCAH221, ZC3HAV1, FOS, SLC30A10, SPRY2, KLF2, HSP70, JUN, ATF3, ETV5, CEMIP, NR4A3
0048731: system development 19 6.46E-05 HBEGF, NEXN, PCDH17, CYR61, TIPARP, HNRNPU, PAPSS2, FOS, CHAC1, SPRY2, KLF2, JUN, ATF3, NR4A3, HNRNPU, NPTX1, MYCL, NPY5R, ERRFI1
0007165: signal transduction 26 4.49E-06 HBEGF, MCHR2, TXK, CYR61, SS2, TIPARP, SOCS1, LOC422147, CCAH221, RGS1, FOS, TNFRSF6B, POMC, SLC30A10, CHAC1, JUN, ATF3, PENK, NR4A3, NYAP2, GNG4, PDK4, RCAN1, NPY5R, TLR15, RRAD
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