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Table 2 Functional annotation of hypothalamic DEGs in response to a variable growth rate of cockerels after 3rd and 6th weeks from hatching that was performed based on STRING and PANTHER tools

From: Identification of candidate genes and regulatory factors related to growth rate through hypothalamus transcriptome analyses in broiler chickens

Gene ontology FDR No. 3-week-old 6-week-old
GO Biological Process COMPLETE
 GO:0098883 synapse pruning 1.35E-02    C1QC, C1QB, C1QA
 GO:0045080 positive regulation of chemokine biosynthetic process 2.01E-02    CD74, MYOD88, EGR1
 GO:0042403 thyroid hormone metabolic process 3.27E-02 3 CRYM, CGA, CPQ  
 GO:0048513 organ development 0.00216 10 BSX, MGP, MMP2, MYH11, EGR1, PCDH15, FST, LECT2, TBX3, NPPC  
 GO:0010469 regulation of signaling receptor activity 2.26E-02 7 GHRH, PMCH, CGA, NMU, POMC, OGN, NPPC  
 GO:0030154 cell differentiation 0.0424 9 MGP, MMP2, MYH11, EGR1, PCDH15, FST, LECT2, NPPC, TAGLN  
 GO:0009914 hormone transport 2.10E-03
3.88E-03
5
7
GHRH, CRYM, CGA, SLCO1C1, TBX3 SLCO1C1, CGA, TBX3, GAL, SLC30A8, BTK, TTR
 GO:0010817 regulation of hormone levels 2.32E-04 4.95E-02 16
13
CRYM, TBX3, GHRH, FGB, SLCO1C1, GGA, BCO1, ALDH6, TCF7L2,CGA, CPLX1, EGR1, CPQ, TRH, CHGA, POMC TBX3, NPY, GAL, DIO2, SLC30A8, SLCO1C1, BLK, TCF7L2, CGA, TTR, NR5A1, EGR1, LHCGR, POMC
 GO:0045187 regulation of circadian sleep/wake cycle 0.0193 3   PER3, KCNA2, GHR
 GO:0002052 positive regulation of neuroblast proliferation 0.0178 3   OTP, DCT, BF1
 GO:0034341 response to interferon-gamma 6.19E-04 7   IRF9, CCL19, IFITM1, GBP1, IRF8, IRF7, IRF1
 GO:0060337 type I interferon signaling pathway 2.88E-02 3   STAT2, STAT1, IRF3
GO molecular function complete
 GO:0071855 neuropeptide receptor binding 5.77E-03 5 GHRH, NPY, NMU, PMCH, POMC  
 GO:0004029 aldehyde dehydrogenase (NAD) activity 2.43E-02 2 ALDH1A1, ALDH6  
 GO:001982 oxygen binding 4.77E-02 2 ALB, HBAD  
 GO:0005179 hormone activity 1.21E-05 11 OXT1, GHRH, ENSGALG00000043381, RFLB, CNP3, NPY, CGA, TRH, AVP, PMCH, NMU, POMC, OXT1, CNP3, NPY, POMC, CGA, GAL, PMCH, TTR, PNOC, KL, CALCA, TTR, CCK,
GO cellular component complete
 GO:0071855 neuropeptide receptor binding 5.77E-03 5 GHRH, NPY, NMU, PMCH, POMC  
 GO:0004029 aldehyde dehydrogenase (NAD) activity 2.43E-02 2 ALDH1A1, ALDH6  
 GO:001982 oxygen binding 4.77E-02 2 ALB, HBAD  
 GO:0005179 hormone activity 1.21E-05 11 OXT1, GHRH, ENSGALG00000043381, RFLB, CNP3, NPY, CGA, TRH, AVP, PMCH, NMU, POMC, OXT1, CNP3, NPY, POMC, CGA, GAL, PMCH, TTR, PNOC, KL, CALCA, TTR, CCK,
GO cellular component complete
 GO:0062023 collagen-containing extracellular matrix 1.63E-03 10 COCH, MMP2, SPARCL1, COL28A1, MGP, COL6A2, COL4A6, COL1A2, COL1A1, EGF  
 GO:0001664 G protein-coupled receptor binding 2.10E-02 13   PNOC, CCLI10, OXT1, GAL, CCL4, PDYN, CCLI7, NPY, RSPO3, PMCH, POMC, CCL19, ENSGALG00000003309
PANTHER GO-Slim Biological Process
 GO:0050796 regulation of insulin secretion 3.85E-03 3 CHGA, TCF7L2, TRH  
 GO:0023056 positive regulation of signaling 4.87E-03 6 GHRH, TCF7L2, TRH  
 GO:0043588 skin development    DSP, COL1A1, ENSGALG00000029182  
 GO:0001501 skeletal system development 1.35E-03 5 COCH, COL6A2, COL6A1, COL1A1, ENSGALG00000029182  
 GO:0007631 feeding behavior 0.03E-01 5 BSX, PMCH, NPW, NMU, NKX2–1, GAL, FOS, PMCH, BSX, STRA6
 GO:0006954 inflammatory response 1.29E-02 8   CCLI10, CCL4,CCR2, CCLI7, TLR1B, TLR2A, TLR3, CCL19
PANTHER Pathway
 T cell activation 4.02E-04 8   RAC2, DMB2, CD3E, B2M, CD3D, LCK, FOS, PTPRC, CD74, FOS, SLP76, CD3D
 B cell activation 1.15E-03 7   BLK, RAC2, BLNK, BTK, PTPN6, FOS, PTPRC
 5-Hydroxytryptamine degredation 8.40E-03 2 ALDH1A1, ALDH6  
 Integrin signalling pathway 1.32E-02 7 COL1A2, COL4A6, COL3A1, COL6A1, COL6A2, ACTA2, COL1A1  
Reactome pathways
 R-GGA-1650814.1 Collagen biosynthesis and modifying enzymes 2.25E-03 5 COL1A2, COL4A6, COL6A1, COL28A1, COL6A2  
 R-GGA-983170.1 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 2.35E-03 5   ERAP1, BFIV21, B2M, BF1, TAP2
 Integrin cell surface interactions 6.70E-03 6 FGB, COL6A2, COL4A6, ENSGALG00000026836, ENSGALG00000004946, COL6A1  
 R-GGA-977606.1 Regulation of Complement cascade 6.21E-05 8 SERPING1, ENSGALG00000030038, C1QC, C1R, CFH, C1S, C1QB, C1QA  
 R-GGA-5686938.1 Regulation of TLR by endogenous ligand 2.58E-02 4 LY96, BPI, TLR1B, TLR2A  
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