Fig. 5

Mutation profile between the two subgroups derived from TCGA-AML data. a-b Mutation profile in the SubgroupA (a) and SubgroupB (b), respectively. Only top 15 genes are shown. c Forest plot of the differentially mutated genes between the two subgroups. Only genes with more than 4 mutations in the samples in one subgroup are included in analysis. The statistical difference of the two groups was compared through the Fisher exact test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. d Hazard ratios for overall survival associated with age (< 57 vs ≥57, median age = 57), subgroup (SubtypeA vs SubtypeB), gender and the number of missense mutations of RUNX1, DNMT3A and PTPN11 in 179 TCGA-AML patients by multivariate Cox regression analysis. The length of the horizontal line represents the 95% confidence interval for each group. OS, Overall survival