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Table 4 The top 30 pathways (emp-P < 0.05) by using PASCAL tool

From: Heritability and genome-wide association analyses of fasting plasma glucose in Chinese adult twins

Pathway chisq-P emp-P -log (chisq-P) -log (emp-P)
BIOCARTA_G1_PATHWAY 1.02E-04 6.10E-06 3.9893 5.21467
KEGG_CELL_CYCLE 3.10E-04 1.36E-04 3.50818 3.86646
REACTOME_PYRIMIDINE_METABOLISM 1.26E-03 1.03E-03 2.90037 2.98716
REACTOME_PYRIMIDINE_CATABOLISM 1.26E-03 1.17E-03 2.90037 2.93181
KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS 1.26E-03 1.42E-03 2.90037 2.84771
KEGG_BETA_ALANINE_METABOLISM 1.26E-03 1.37E-03 2.90037 2.86328
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 1.42E-03 1.73E-03 2.84744 2.76195
REACTOME_REGULATION_OF_INSULIN_SECRETION 1.64E-03 2.55E-03 2.78464 2.59346
BIOCARTA_P38MAPK_PATHWAY 1.83E-03 4.87E-04 2.7375 3.31247
REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION 1.99E-03 2.10E-03 2.7012 2.67778
BIOCARTA_IL1R_PATHWAY 2.06E-03 5.20E-04 2.68591 3.284
REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 2.11E-03 2.31E-03 2.67517 2.63639
BIOCARTA_SKP2E2F_PATHWAY 2.11E-03 1.94E-03 2.67517 2.7122
BIOCARTA_RACCYCD_PATHWAY 2.11E-03 1.90E-03 2.67517 2.72125
BIOCARTA_MCM_PATHWAY 2.11E-03 2.04E-03 2.67517 2.69037
KEGG_PYRIMIDINE_METABOLISM 2.12E-03 1.51E-03 2.67276 2.82102
REACTOME_SIGNALING_BY_PDGF 2.49E-03 2.37E-03 2.60427 2.62525
KEGG_TASTE_TRANSDUCTION 2.64E-03 3.83E-03 2.5779 2.4168
REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE 2.69E-03 3.02E-03 2.56976 2.51999
BIOCARTA_FMLP_PATHWAY 2.69E-03 2.60E-03 2.56976 2.58503
BIOCARTA_NKT_PATHWAY 2.73E-03 9.20E-04 2.56384 3.03621
BIOCARTA_TOB1_PATHWAY 2.82E-03 2.87E-03 2.55023 2.54212
BIOCARTA_TGFB_PATHWAY 2.82E-03 3.01E-03 2.55023 2.52143
BIOCARTA_ALK_PATHWAY 2.82E-03 3.05E-03 2.55023 2.5157
KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 2.85E-03 2.82E-03 2.54489 2.54975
REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 3.05E-03 1.78E-03 2.51614 2.74958
REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION 3.06E-03 2.88E-03 2.5141 2.54061
REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA 3.06E-03 2.82E-03 2.5141 2.54975
BIOCARTA_RELA_PATHWAY 3.06E-03 2.99E-03 2.5141 2.52433
BIOCARTA_RARRXR_PATHWAY 3.06E-03 3.06E-03 2.5141 2.51428