Exploring the possibility of predicting human head hair greying from DNA using whole-exome and targeted NGS data

BMC Genomics

Table 1 Selection of exome-wide significant (P-value < 5 × 10^− 4) and replicated (P-value < 0.05) SNPs associated with hair greying in a discovery and replication cohorts of 149 and 849 individuals from Poland, respectively

SNP_ID	Chr position GRCh38	Gene	fMA	BLR		MLR3		MLR6
SNP_ID	Chr position GRCh38	Gene	fMA	beta	P-value^a	beta	P-value^a	beta	P-value^a
Discovery cohort (N = 149);P-value < 5 × 10^− 4
rs59733750	2:240780193	KIF1A	G 0.144	−1.782	0.013	−1.787	0.002	−1.861	2.798 × 10⁻⁴
rs1127228	16:27226789	NSMCE1	T 0.362	−1.360	0.005	−1.452	4.312 × 10⁻⁴	−1.404	1.227 × 10^− 4
Replication cohort (N = 849);P-value < 0.05
rs59733750	2:240780193	KIF1A	G 0.163	−0.484	0.007	−0.541	0.002	−0.569	5.473 × 10⁻⁴
rs1127228	16:27226789	NSMCE1	T 0.347	−0.241	0.079	−0.314	0.015	−0.283	0.022

BLR, binomial logistic regression; MLR3, multinomial ordinal logistic regression for 3 hair greying categories; MLR6, multinomial ordinal logistic regression for 6 hair greying categories; MA, minor allele; fMA, frequency of minor allele
^aResults adjusted for age, sex and hair colour

ISSN: 1471-2164